187724-61-4
PKI-166
CAS: 187724-61-4
Molecular Formula: C20H18N4O
187724-61-4 - Names and Identifiers
187724-61-4 - Physico-chemical Properties
| Molecular Formula | C20H18N4O |
| Molar Mass | 330.38 |
| Solubility | DMSO: soluble10mg/mL, clear |
| Appearance | Solid |
| Color | white to beige |
| Storage Condition | 2-8°C |
187724-61-4 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
187724-61-4 - Reference Information
| biological activity | PKI-166 is a highly potent, selective, orally bioactive EGFR tyrosine kinase inhibitor, the IC50 value was 0.7 nM. |
| Target | IC50: 0.7 nM (EGFR tyrosine kinase) |
| Cell Line: | L3.6pl cells L3.6pl cells |
| Concentration: | 0.01 μM, 0.05 μM, 0.5 μM 0.03 μM |
| Incubation Time: | 1 hour 6 days |
| Result: | Inhibited EGFR autophosphorylation in a dose-dependent manner. Enhanced the cytotoxicity mediated by gemcitabine. Significantly decreased median tumor volume. |
| Animal Model: | Male athymic nude mice with L3.6pl cells xenograft (8–12 weeks) |
| Dosage: | 100 mg/kg |
| Administration: | Oral administration; daily; from day 7 to day 35 after xenograft |
Last Update：2024-04-10 22:29:15
