18942-26-2
Chebulinic acid
CAS: 18942-26-2
Molecular Formula: C41H32O27
18942-26-2 - Names and Identifiers
| Name | Chebulinic acid |
| Synonyms | NSC69862 Eutannin CHEBULINIC ACID Chebulinic acid CHEBULINIC ACID(SH) |
| CAS | 18942-26-2 |
18942-26-2 - Physico-chemical Properties
| Molecular Formula | C41H32O27 |
| Molar Mass | 956.68 |
| Density | 2.04 |
| Melting Point | 234°C |
| Boling Point | 1460.0±65.0 °C(Predicted) |
| Specific Rotation(α) | (c, 1.0 in Me2CO)-65.1 |
| Solubility | Soluble in DMSO |
| Appearance | Yellow powder |
| pKa | 4.14±0.10(Predicted) |
| Storage Condition | -20°C |
| Physical and Chemical Properties | White crystalline powder. |
| In vitro study | In vitro: binding of Chebulinic acid causes displacement of catalytic Tyr129 away from its target DNA-phosphate molecule. [1] Chebulinic acid reduce the expression and activity of MMP-2 at an ED50 value of 100 μM. EMT (Epithelial to Mesenchymal Transition) is found to be induced in ARPE-19 cells, through SMAD-3 phosphorylation and it is inhibited by CA. [2] chebulinic acid significantly inhibited H+ K+-ATPase activity in vitrowith IC50 of 65.01 μg/ml. [3] |
18942-26-2 - Risk and Safety
| WGK Germany | 3 |
18942-26-2 - Reference
| Reference Show more | 1. Wu Lingfang, Liang Wenyi, Zhang Lanzhen. Study on the determination of main components in Tibetan medicine Phyllanthus emblica [J]. World Science and Technology-modernization of traditional Chinese medicine, 2020,22(08):2857-2863. 2. [IF = 2.833] Wang Min et al."Chebulinic acid derived from triphala is a promising antitumor agent in human colorrectal carcinoma cell lines." Bmc Complem Altern M. 2018 Dec;18(1):1-9 3. [IF = 2.833] Wang Min et al."Chebulinic acid derived from triphala is a promising antitumor agent in human colorrectal carcinoma cell lines." Bmc Complem Altern M. 2018 Dec;18(1):1-9 4. [IF = 2.478] Kun Li et al."Composition, Antivirulence Activity, and Active Property Distribution of the Fruit of Terminalia chebula Retz."J Food Sci. 2019 Jul;84(7):1721-1729 |
18942-26-2 - Reference Information
| biological activity | Chebulinic acid is a natural M. tuberculosis DNA gyrase inhibitor, which can also inhibit the activity of SMAD-3 phosphorylation and H K -ATPase. |
| target | target: M. tuberculosis DNA gyrase[1], SMAD-3 phosphorylation[2], H K -ATPase activity.[3] IC50: 65.01 μg/ml ( H K -ATPase ) [3] |
| in vitro study | in vitro: binding of Chebulinic acid displacement of catalytic Tyr129 away from its target DNA-phosphate molecule. [1] Chebulinic acid reduce the expression and activity of MMP-2 at an ED50 value of 100 μ m EMT (Epithelial to Mesenchymal Transition) is found to be induced in ARPE-19 cells, through SMAD-3 phosphorylation and it is inhibited by CA. [2] chebulinic acid significantly inhibited H K -ATPase activity in vitrowith IC50 of 65.01 μg/ml. [3] |
| chemical properties | white crystalline powder. |
| use | used for content determination/identification/pharmacological experiments, etc. |
Last Update：2024-04-10 22:29:15
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Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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