1898283-02-7

1898283-02-7 - Names and Identifiers

Name	2-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl)propan-2-ol
Synonyms	CS-2805 LY-3200882 2-[4-[[4-[1-cyclopropyl-3-(oxan-4-yl)pyrazol-4-yl]oxypyridin-2-yl]amino]pyridin-2-yl]propan-2-ol 2-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl)propan-2-ol 4-[[4-[[1-Cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]oxy]-2-pyridinyl]amino]-α,α-dimethyl-2-pyridinemethanol 2-Pyridinemethanol, 4-[[4-[[1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]oxy]-2-pyridinyl]amino]-α,α-dimethyl-
CAS	1898283-02-7

1898283-02-7 - Physico-chemical Properties

Molecular Formula	C24H29N5O3
Molar Mass	435.52
Density	1.36±0.1 g/cm3(Predicted)
Boling Point	607.2±55.0 °C(Predicted)
pKa	13.45±0.29(Predicted)
Storage Condition	-20℃
In vitro study	LY3200882 inhibits the activity of multiple proto-oncogenes. LY3200882 can effectively inhibit TGFβ-mediated SMAD phosphorylation in tumor cells and immune cells in vitro, TGFβ-mediated SMAD phosphorylation was inhibited in a concentration-dependent manner. In an in vitro immunosuppression assay, LY3200882 can rescue the initial T cell activity of TGFβ1 inhibited or regulatory T cell inhibited and restore proliferation. LY3200882 is an immunomodulator.
In vivo study	LY3200882 has potent anti-tumor activity in an in situ 4T1-LP triple negative breast cancer model, which is associated with tumor-infiltrating lymphocytosis. LY3200882 can cause persistent tumor regression and complete rejection of secondary stimulation of syngeneic tumors. LY3200882 has anti-metastatic activity in an experimental metastasis model (intravenous injection EMT6-LM2, triple negative breast cancer model). In addition, in the syngeneic CT26 model, LY3200882 co-administered with anti-PD-L1 had a combined antitumor benefit.

1898283-02-7 - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	2.296 ml	11.481 ml	22.961 ml
5 mM	0.459 ml	2.296 ml	4.592 ml
10 mM	0.23 ml	1.148 ml	2.296 ml
5 mM	0.046 ml	0.23 ml	0.459 ml

Last Update：2024-01-02 23:10:35

1898283-02-7 - Introduction

2-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl)propan-2-ol) is a compound with the chemical structure C27H41F3N4O4. It is a glucocorticoid receptor antagonist that interacts with the glucocorticoid receptor and blocks its activity. In addition, 2-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl)propan-2-ol also have anti-inflammatory and immunosuppressive effects.

2-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl) the preparation method of propan-2-ol is synthesized by organic synthesis method. The specific synthesis process can be complex and requires specialized chemical knowledge.

Safety information about 2-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl)propan-2-ol, according to the information currently available, the compound is relatively safe under normal conditions of use. However, the use of the process still requires careful handling and follow the relevant safety guidelines. Before use, it is recommended to consult a professional physician or refer to the product manual for more detailed and up-to-date safety information.

Last Update：2024-04-09 21:54:55