190383-13-2

190383-13-2 - Names and Identifiers

Name	H-SER-LEU-ILE-GLY-LYS-VAL-NH2
Synonyms	SLIGKV-NH2 SLIGKVAMIDE PAR2-AP(SLIGKV-NH2) SER-LEU-ILE-GLY-LYS-VAL-NH2 SER-LEU-ILE-GLY-LYS-VAL-AMIDE H-SER-LEU-ILE-GLY-LYS-VAL-NH2 PAR-2 AGONIST PEPTIDE (SLIGKV) AMIDE, HUMAN PROTEASE-ACTIVATED RECEPTOR-2 AGONIST, AMIDE PROTEINASE ACTIVATED RECEPTOR 2 (1-6) AMIDE (HUMAN) PROTEINASE ACTIVATED RECEPTOR 2 AGONIST PEPTIDE SLIGKV AMIDE, HUMAN
CAS	190383-13-2

190383-13-2 - Physico-chemical Properties

Molecular Formula	C28H54N8O7
Molar Mass	614.78
Appearance	solid
Storage Condition	-20°C
In vitro study	The PAR2-activating peptides used are: SLIGKV-OH, SLIGRL-OH, SLIGKV-NH 2 , SLIGRL-NH 2 . The synthetic agonist peptides mimicking the tethered ligand of PAR2, Ser-Leu-Ile-Gly-Lys-Val (SLIGKV-OH), Ser-Leu-Ile-Gly-Arg-Leu (SLIGRL-OH) and their amidated forms Ser-Leu-Ile-Gly-Lys-Val-amide (SLIGKV-NH 2 ) Ser-Leu-Ile-Gly-Arg-Leu-amide (SLIGRL-NH 2 ) have also been demonstrated being able to activate the receptor without enzymatic cleavage, therefore, have been utilised as biological tools to examine physiological functions of PAR2. Protease-Activated Receptor-2, amide is one of a four family subgroup of G-protein-coupled receptors (GPCRs), called PARs. Protease-activated receptors are distinguished from other GPCRs through their unique proteolytic mechanism of activation. For PAR2, activating proteases, such as trypsin, tryptase and coagulation factors VIIa and Xa, cleave a specific extracellular amino-terminal domain of the receptor to reveal a "tethered ligand", SLIGKV- and SLIGRL- for human and mouse/rat PAR2, respectively, which subsequently interacts with the activation domain of the receptor, initiating intracellular signaling pathways. The protease-activated receptor-2 (PAR2) has been implicated in the pathogenesis of several inflammatory and autoimmune disorders, and is expressed in a wide variety of human tissues and cells. PAR2 belongs to a family of seven transmembrane domain receptor proteins that are activated by proteolysis. Enzymatic digestion exposes an N-terminus ligand sequence that binds intramolecularly to the activation site on the extracellular loop II, initiating a G-protein-mediated cell-signalling cascade and nuclear factor-kappa B (NF-κB)-regulated gene transcription.