1913269-12-1

Molecular Formula	C26H32ClN2O8PS
Molar Mass	599.03
Solubility	DMSO
Storage Condition	-20℃
In vitro study	After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H + , K + -ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca 2+ -independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93.

Last Update：2024-01-02 23:10:35

biological activity	KN-93 is a calcium ion/calmodulin-dependent kinase II(CaMKII) inhibitor, capable of competitively blocking the binding of calmodulin to the corresponding kinase, the Ki is 370 nM.
Target	Ki: 370 nM (CaMK-II)

Last Update：2024-04-09 15:16:56

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Product Name: KN-93 (phosphate) Visit Supplier Webpage Request for quotation
CAS: 1913269-12-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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1913269-12-1

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