19237-84-4
prazosin hydrochloride
CAS: 19237-84-4
Molecular Formula: C19H22ClN5O4
19237-84-4 - Names and Identifiers
| Name | prazosin hydrochloride |
| Synonyms | Prazosin HCl Prazosin hydrochlori prazosin hydrochloride Prazosin Hydrochloride (500 mg) 4-Amino-2-pyroyl-6,7-dimetoxypiperazin-1-yl-chynazolina hydrochloride 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazinehydr [4-(4-AMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanylMethanone Hydrochloride [4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone hydrochloride Furazosin hydrochloride, 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride Prazosin hydrochloride,1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride, Furazosin hydrochloride |
| CAS | 19237-84-4 |
| EINECS | 242-903-4 |
| InChI | InChI=1/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H |
| InChIKey | WFXFYZULCQKPIP-UHFFFAOYSA-N |
19237-84-4 - Physico-chemical Properties
| Molecular Formula | C19H22ClN5O4 |
| Molar Mass | 419.86 |
| Melting Point | 277 - 280°C |
| Boling Point | 638.4°C at 760 mmHg |
| Flash Point | 339.9°C |
| Water Solubility | Soluble in dimethyl sulfoxide, ethanol, water, methanol. |
| Solubility | Soluble in dimethyl sulfoxide, ethanol, water, methanol. |
| Vapor Presure | 3.4E-16mmHg at 25°C |
| Appearance | off-white to yellow powder |
| Color | white |
| Merck | 14,7717 |
| BRN | 4303561 |
| Storage Condition | 2-8°C |
| MDL | MFCD00058177 |
| Physical and Chemical Properties | Appearance: white or white crystalline powder moisture: less than or equal to 2.0% (anhydrous prazosin),<8-15% (hydrous prazosin) ignition residue: less than or equal to 0.4% heavy metals: ≤ 50ppm related substances: in accordance with the provisions of the content: according to the anhydrous C19H21N5O4HCL, not less than 99.0%, not more than 102.0 |
| Use | Used as an antihypertensive agent |
19237-84-4 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R62 - Possible risk of impaired fertility |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S36 - Wear suitable protective clothing. |
| UN IDs | 3249 |
| WGK Germany | 3 |
| RTECS | VA1350000 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 2934990002 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
19237-84-4 - Standard
Authoritative Data Verified Data
This product is l-(4-amino -6, 7-dimethoxy-2-quinazolinyl)-4-(2-furanformyl) piperazine hydrochloride. The content of C19H21N504 • HCl shall not be less than 98.0% calculated on a dry basis.
Last Update：2024-01-02 23:10:35
19237-84-4 - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; Odorless.
- This product is slightly soluble in ethanol and almost insoluble in water.
Last Update：2022-01-01 15:07:01
19237-84-4 - Differential diagnosis
Authoritative Data Verified Data
- take about 0.1kg of this product, add the same amount of sodium carbonate, mix well, and place it in a dry test tube. The nozzle is covered with test paper moistened with 1% sodium 1, 2-naphthoquinone-4-sulfonate solution. After burning at the bottom of the test tube, the test paper should show Pansy color.
- take this product, dissolve and dilute with ethanol to make a solution containing about 5ug per lml, and measure by UV-Vis spectrophotometry (General 0401), there is an absorption maximum at a wavelength of 251nm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 375).
- the aqueous solution of this product can identify the reaction of (1) (General rule 0301).
Last Update：2022-01-01 15:07:01
19237-84-4 - Exam
Authoritative Data Verified Data
acidity
take 0.30g of this product, add water 20ml, shake, filter, take the filtrate, according to the law (General 0631), pH value should be 3.0~4.5.
Related substances
take this product, add the mobile phase to dissolve and dilute to make a solution containing about lmg per lml as a test solution; Take lml for precision measurement and put it in a 200ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. According to the high performance liquid chromatography (General 0512) test, silica gel was bonded with eighteen alkyl silane as the filler; pH 5.0 buffer solution (3.64g of sodium pentanesulfonate and g of tetramethylammonium hydroxide) was used, 5.0 ml of water was added to dissolve, and the pH value was adjusted to with glacial acetic acid)-methanol (50:50) as mobile phase; The detection wavelength was 254nm. Take appropriate amounts of metoclopramide and prazosin hydrochloride, add mobile phase to dissolve and dilute to prepare solutions containing 32ug and 4ug per lml respectively. Inject 20u1 into human liquid chromatograph and record chromatogram, the theoretical plate number is not less than 2000 calculated by prazosin peak, and the resolution of metoclopramide peak and prazosin peak should be greater than 8.0. 20 u1 of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 4 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.4 times (0.2%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (0.5%).
inulin
take this product l. Add 10ml of water, slightly warm for 10 minutes, centrifuge after shaking, take the supernatant, according to Gas chromatography (General 0521), A high molecular porous pellet of divinylbenzene-ethylvinylbenzene type having a diameter of 0.25 to 0.18 was used as a stationary phase and measured at a column temperature of 150°C. Containing isoamyl alcohol should not exceed 0.1%(g/g).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 1.0% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
Iron
take this product l.Og, add 1.5ml of nitric acid Dropwise, place until no smoke is generated, water bath is heated and evaporated, and slowly rise to 150°C at 1000°C for 1 hour, cool, 20ml of dilute hydrochloric acid was added to dissolve the residue, and the solution was evaporated to about 5ml on the water bath. Then, the solution was quantitatively transferred to a 25ml measuring flask with dilute hydrochloric acid, and diluted to the scale; separately, the iron single element standard solution was quantitatively diluted with dilute hydrochloric acid to prepare a solution containing 2UG, 4UG and 6ug of iron per 1 ml, respectively, as a reference solution. According to Atomic Absorption Spectrophotometry (General rule 0406 method 1), measured at a wavelength of NM and calculated. Iron content should not exceed 0.01%.
nickel
take the test solution under the iron inspection item as the test solution; Take the nickel single element standard solution and quantitatively dilute it with dilute hydrochloric acid to make each lml containing nickel lug, 2ug and 3ug solution, as a reference solution. According to Atomic Absorption Spectrophotometry (General rule 0406 first method), measured at a wavelength of 232.Onm, calculated. The nickel content should not exceed 0.005%.
Last Update：2022-01-01 15:07:02
19237-84-4 - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
The mobile phase was methanol-water-glacial acetic acid-diethylamine (700:300:10:0.2) and the detection wavelength was 254mn. The theoretical plate number is not less than 2000 calculated as the prazosin peak.
assay
take an appropriate amount of this product, accurately weigh it, add methanol to dissolve and quantitatively dilute it to make a solution containing about 1 mg per 1 ml. Take 3ml for precision measurement and put it in a 100ml measuring flask, dilute to the scale with methanol-water (7:3), shake well, precisely take 10u1 and inject human liquid chromatograph, record the chromatogram; Take an appropriate amount of prazosin hydrochloride reference, precisely weigh, same method determination. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 15:07:03
19237-84-4 - Category
Authoritative Data Verified Data
antihypertensive drugs.
Last Update：2022-01-01 15:07:03
19237-84-4 - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 15:07:03
19237-84-4 - Prazosin Hydrochloride Tablets
Authoritative Data Verified Data
This product contains prazosin hydrochloride (C19H21N504 • HCl) should be 90.0% to 110.0% of the label.
trait
This product is white tablet.
identification
- take an appropriate amount of fine powder of this product (about 20mg equivalent to prazosin hydrochloride), add 10% ml of 1.5 sodium hydroxide solution, grind for 5 minutes, add 10ml of three gas methane, shake for 15 minutes, and let stand, after stratification, the chloroform layer was filtered, the filtrate was evaporated to dryness, and the extract showed the same reaction according to the identification (1) Test under the item of prazosin hydrochloride .
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- take an appropriate amount of fine powder of this product, add water, shake, filter, filtrate shows chloride to identify (1) reaction (General rule 0301).
examination
- Related substances take the fine powder of this product, add mobile phase to dissolve prazosin hydrochloride and dilute it to prepare a solution containing about 1 mg per 1ml, filter it, and take the continued filtrate as the test solution; take 1ml accurately, put in 200ml measuring flask, add mobile phase diluted to the scale, shake, as a control solution. The determination was carried out according to the method for related substances of prazosin hydrochloride. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.5% ) , the sum of each impurity peak area shall not be greater than 2 times (1.0%) of the main peak area of the control solution.
- Content uniformity take 1 tablet of this product, put 25ml(0.5mg specification) or 50ml( lmg specification) or 100ml(2mg specification) measuring flask, add methanol-water-glacial acetic acid (96:2:2) appropriate amount, ultrasonic to dissolve prazosin hydrochloride, cool, dilute to the scale with methanol-water-glacial acetic acid (96:2:2), shake well, centrifuge, take the supernatant as the test solution; Take the prazosin hydrochloride control, precision weighing, plus methanol-water-glacial acetic acid (96:2:2) dissolve and quantitatively dilute to make a solution containing about 20ug per 1 ml as a control solution. Determination according to the method under the content determination item, should comply with the provisions (General 0941).
- dissolution of this product, according to the dissolution and release determination method (General 0931 second method), with 0.500ml of 1 mol/L hydrochloric acid solution is the dissolution medium, and the rotation speed is 75 revolutions per minute, and the operation is carried out according to law. After 30 minutes, 10ml of the solution is taken, filtered, and the filtrate is taken as the test solution; another 20mg of prazosin hydrochloride reference product was added into a 100ml measuring flask, dissolved with anhydrous ethanol and diluted to the standard, then the sample was shaken, and 2ml was added into a 200ml measuring flask, use 0.1 mol/L hydrochloric acid solution was diluted to the scale and shaken as a reference solution. The test solution and the reference solution were taken, and the absorbance was measured at the wavelength of 246mn by ultraviolet-visible spectrophotometry (General rule 0401), and the dissolution amount of each tablet was calculated. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using silica gel as filler, 0.01% diethylamine methanol solution-water-glacial acetic acid (96:2:2) as mobile phase, the detection wavelength was 254nm. The theoretical plate number is not less than 2000 calculated as the prazosin peak.
- determination of 20 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (equivalent to 2mg of prazosin hydrochloride), put in a 100ml measuring flask, add methanol-water-glacial acetic acid (96:2:2) appropriate amount, ultrasonic dissolution of prazosin hydrochloride, let cool, with methanol-water-glacial acetic acid (96:2:2) dilute to the scale, shake, centrifuge, take the supernatant as the test solution, take 20 u1 with precision, inject human liquid chromatograph, record the chromatogram; another precision weighing prazosin hydrochloride reference, precision weighing, plus methanol-water-glacial acetic acid (96:2:2) dissolved and quantitatively diluted to make a solution containing about 20ug per 1 ml, same method determination. According to the external standard method to calculate the peak area, that is.
category
with prazosin hydrochloride.
specification
(1)0.5mg (2)lmg (3)2mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 15:07:04
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