196868-63-0

Name	PQ 401
Synonyms	PQ401 PQ 401 IGF-1R Inhibitor II N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)- 1-(5-Chloro-2-Methoxyphenyl)-3-(2-Methylquinolin-4-yl)urea N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea Urea, N-(5-chloro-2-Methoxyphenyl)-N'-(2-Methyl-4-quinolinyl)- IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
CAS	196868-63-0

Molecular Formula	C18H16ClN3O2
Molar Mass	341.79
Density	1.370±0.06 g/cm3 (20 ºC 760 Torr)
Solubility	25°C: DMSO 32 mg/mL (93.62 mM);Water <1 mg/mL (<1 mM);Ethanol <1 mg/mL (<1 mM)
Appearance	White solid
Color	white
Storage Condition	Sealed in dry,2-8°C
MDL	MFCD00160558
Use	An inhibitor of IGF-1R autophosphorylation.
In vitro study	PQ 401 is a IGF-1R inhibitor, and inhibits the phosphorylation of the kinase domain by IGF-IR at a concentration of <100 nM, with an IC50 < 1 μm. PQ 401 significantly reduces MCF-7 cell proliferation with an IC50 of 8 μm. PQ 401 also inhibited the growth of MCNeuA cells with an IC50 of 15 μm. PQ 401 acts on MCF-7 cells and inhibits IGF-I of the regulated anti-apoptotic pathway. PQ 401 acts on MCF-7 cells to enhance caspase-regulated apoptotic activity. PQ 401 is a IGF-1R inhibitor that inhibits the autophosphorylation of the kinase domain by IGF-IR at concentrations <100 nM with an IC50 < 1 μm. PQ 401 significantly reduced the proliferation of MCF-7 cells with IC50 of 8 μm. PQ 401 also inhibited the growth of MCNeuA cells with an IC50 of 15 μm. PQ 401 acts on MCF-7 cells and inhibits IGF-I of the regulated anti-apoptotic pathway. PQ 401 acts on MCF-7 cells to enhance caspase-regulated apoptotic activity.
In vivo study	PQ 401(50 mg/Kg,100 mg/Kg) significantly inhibited MCNeuA tumor growth in a dose-dependent manner. PQ 401(50 mg/Kg,100 mg/Kg) significantly inhibited MCNeuA tumor growth in a dose-dependent manner.

Hazard Symbols	T - Toxic
Risk Codes	25 - Toxic if swallowed
Safety Description	45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2811 6.1/PG 3
WGK Germany	3

PQ 401 inhibited autophosphorylation in the IGF-1R region with an IC50 of less than 1 μM.

Last Update：2022-10-16 17:41:31

biological activity	PQ 401 inhibits autophosphorylation of IGF-1R region, IC50 is less than 1 μM. PQ 401 inhibits autophosphorylation of IGF-1R region with IC50 less than 1 μM.
in vitro study	PQ 401 is a IGF-1R inhibitor. when the concentration is <100 nM, it inhibits autophosphorylation of IGF-IR kinase domain, IC50 < 1 μM. PQ 401 significantly reduces MCF-7 cell proliferation, IC50 is 8 μM. PQ 401 also inhibited MCNeuA cell growth with an IC50 of 15 μM. PQ 401 acts on MCF-7 cells and inhibits IGF-I-regulated anti-apoptotic pathways. PQ 401 acts on MCF-7 cells to enhance caspase-regulated apoptotic activity. PQ 401 is a IGF-1R inhibitor. when the concentration is <100 nM, it inhibits autophosphorylation of IGF-IR kinase domain, IC50 < 1 μM. PQ 401 significantly reduces MCF-7 cell proliferation, IC50 is 8 μM. PQ 401 also inhibited MCNeuA cell growth with an IC50 of 15 μM. PQ 401 acts on MCF-7 cells and inhibits IGF-I-regulated anti-apoptotic pathways. PQ 401 acts on MCF-7 cells to enhance caspase-regulated apoptotic activity.
in vivo study	PQ 401(50 mg/Kg,100 mg/Kg) significantly inhibited MCNeuA tumor growth, which is dose-dependent. PQ 401(50 mg/Kg,100 mg/Kg) significantly inhibited MCNeuA tumor growth in a dose-dependent manner.
target	TargetValue IGF-1R <1 μM
Target	Value
IGF-1R	<1 μM

Last Update：2024-04-09 01:59:58

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CAS: 196868-63-0
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Mobile: 18021002903
QQ: 3008007409

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196868-63-0

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