19745-07-4
2,5-Dichloropyrazine
CAS: 19745-07-4
Molecular Formula: C4H2Cl2N2
19745-07-4 - Names and Identifiers
| Name | 2,5-Dichloropyrazine |
| Synonyms | NSC 349788 2,5-Dichloroprazine 2,5-Dichloropyrazine 2,5-DICHLOROPYRAZINE Pyrazine, 2,5-dichloro- 2,5-Dichloro-1,4-diazine |
| CAS | 19745-07-4 |
| InChI | InChI=1/C4H2Cl2N2/c5-3-1-7-4(6)2-8-3/h1-2H |
19745-07-4 - Physico-chemical Properties
| Molecular Formula | C4H2Cl2N2 |
| Molar Mass | 148.98 |
| Density | 1.493±0.06 g/cm3(Predicted) |
| Melting Point | 0 °C (approx) |
| Boling Point | 184.4±35.0 °C(Predicted) |
| Flash Point | 81.5°C |
| Vapor Presure | 1mmHg at 25°C |
| Appearance | Yellow liquid |
| pKa | -4.23±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.559 |
19745-07-4 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| HS Code | 29339900 |
19745-07-4 - Reference Information
| Application | 2,5-dichloropyrazine is a pharmaceutical intermediate that can be chlorinated from pyrazine-2-amine to obtain 5-chloropyrazine-2-amine, and then 2, 5-dichloropyrazine is obtained by diazotization reaction. |
| Preparation | Step 1: Synthesis of 5-chlorpyrazine-2-amine Under nitrogen, NCS(4.2g,30.545mmol) is added to the stirred solution of pyrazine-2-amine (3g,31.545mmol) in anhydrous DCM(30mL), and stirred at 40°C for 2h. The reaction progress was monitored by TLC. After the reaction is complete, DCM is added and washed with water. The organic layers were dried with sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel (100-200 mesh) column chromatography using 20% ethyl acetate in hexane as eluent to obtain 5-chlorpyrazine-2-amine (0.59g,15%) as a yellow solid. Step 2: Synthesis of 5-dichloropyrazine At -10°C, add sodium nitrite aqueous solution (1.1g,15.89mmol) to the stirred solution of 5-chloropyrazine-2-amine (1g,7.751mmol) in concentrated HCl(10mL) within 1h, stir at 0°C for 1h, and then stir at RT for 2h. The reaction progress was monitored by TLC. After the reaction is completed, the reaction material is neutralized in 50% NaOH solution and extracted with DCM. The organic layers were dried with sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel (100-200 mesh) column chromatography using 2% ethyl acetate in hexane as eluent to obtain 2,5-dichloropyrazine (0.59g,15%) as a colorless oil. |
Last Update：2024-04-09 15:16:48
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View History
19745-07-4
3,4-(ETHYLENEDIOXY)BENZENEBORONIC ACID
4-[5-(Trifluoromethyl)pyridin-2-yl]benzenecarboxaldehyde 95%
trisodium 6-[(7-amino-1-hydroxy-3-sulphonato-2-naphthyl)azo]-3-[[4-[[4-amino-6(or 7)-sulphonatonaphthyl]azo]phenyl]azo]-4-hydroxynaphthalene-2-sulphonate
11C,14C-Eicosadienoic Acid
Ethyl--D-6-glucuronide
1,3-Benzenedicarboxaldehyde, 5-hydroxy- (9CI)
3-(methyl(2-morpholinoethyl)carbamoyl)benzoic acid
1-氯代丙烷
1-[2-Chloro-5-methyl-4-(methylsulphonyl)phenyl]piperidine-3-carboxylic acid
3,4-(ETHYLENEDIOXY)BENZENEBORONIC ACID
4-[5-(Trifluoromethyl)pyridin-2-yl]benzenecarboxaldehyde 95%
trisodium 6-[(7-amino-1-hydroxy-3-sulphonato-2-naphthyl)azo]-3-[[4-[[4-amino-6(or 7)-sulphonatonaphthyl]azo]phenyl]azo]-4-hydroxynaphthalene-2-sulphonate
11C,14C-Eicosadienoic Acid
Ethyl--D-6-glucuronide
1,3-Benzenedicarboxaldehyde, 5-hydroxy- (9CI)
3-(methyl(2-morpholinoethyl)carbamoyl)benzoic acid
1-氯代丙烷
1-[2-Chloro-5-methyl-4-(methylsulphonyl)phenyl]piperidine-3-carboxylic acid