19767-45-4
sodium 2-mercaptoethanesulfonate
CAS: 19767-45-4
Molecular Formula: C2H5NaO3S2
19767-45-4 - Names and Identifiers
| Name | sodium 2-mercaptoethanesulfonate |
| Synonyms | Mesna MESNA MESNEX mesnaum COENZYME M MESNA SODIUM SALT 2-mercaptoethanesulfonic sodium 2-mercaptoethanesulfonate sodium 2-sulfanylethanesulfonate MERCAPTOETHANESULFONIC ACID SODIUM SALT 2-Mercaptoethanesulphonicacid,sodiumsalt 2-Mercaptoethanesulfonic acid sodium salt 2-mercaptoethanesulfonicacidmonosodiumsalt |
| CAS | 19767-45-4 |
| EINECS | 243-285-9 |
| InChI | InChI=1/C2H6O3S2.Na/c3-7(4,5)2-1-6;/h6H,1-2H2,(H,3,4,5) |
19767-45-4 - Physico-chemical Properties
| Molecular Formula | C2H5NaO3S2 |
| Molar Mass | 164.18 |
| Melting Point | >240°C dec. |
| Water Solubility | Soluble in water. Also soluble in methanol, DMSO (33 mg/ml) and ethanol (<1 mg/ml). |
| Solubility | 200 mg plus 4.0 mL, H2O |
| Appearance | White powder |
| Color | White to Off-White |
| Merck | 14,5909 |
| BRN | 3657828 |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| MDL | MFCD00007535 |
| Use | Respiratory system medication |
| In vitro study | Mesna (1-1000 μM) reduces H 2 O 2 , HOCl and OH• concentrations in a dose-dependent manner, with an IC 50 of 32, 21, and 305 μM, respectively in cell-free experiments. |
19767-45-4 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 2 |
| RTECS | KI7968000 |
| HS Code | 2930 90 98 |
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 1887, 2048, 2098, 1683 i.v.; 2005, 2098, 1529, 1251 i.p.; 6102, >7200, 4440, 4679 orally (Brock) |
19767-45-4 - Reference Information
| biological activity | Mesna is a sulfhydryl compound used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. |
| Animal Model: | Adult male Wistar Albino rats (250-350 g) are suffered traumatic brain injury (TBI) |
| Dosage: | 150 mg/kg |
| Administration: | A single i.p. |
| Result: | Decreased tissue malondialdehyde levels. Increased the activity of glutathione peroxidase and superoxide dismutase. Decreased the levels of nitric oxide, nitric oxide synthetase and xanthine oxidase. Protected the brain tissues well from injury. |
| use | respiratory system medication. |
Last Update：2024-04-09 20:52:54
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