19968-85-5

19968-85-5 - Names and Identifiers

Name	1-Aminomethyl-1-cyclohexanol hydrochloride
Synonyms	TIMTEC-BB SBB003901 1-Aminomethyl-1-cyclohexanolHCl 1-Aminomethyl-1-cyclohexanol hydrochl 1-(Aminomethyl)cyclohexanol hydrochloride 1-AMINOMETHYL-1-CYCLOHEXANOL HYDROCHLORIDE 1-Aminomethyl-1-cyclohexanol hydrochloride
CAS	19968-85-5
EINECS	243-444-2
InChI	InChI=1/C7H15NO/c8-6-7(9)4-2-1-3-5-7/h9H,1-6,8H2/p+1

19968-85-5 - Physico-chemical Properties

Molecular Formula	C7H16ClNO
Molar Mass	165.66
Melting Point	217-219°C(lit.)
Boling Point	219.5°C at 760 mmHg
Flash Point	86.6°C
Vapor Presure	0.025mmHg at 25°C
Appearance	Powder
Color	White to grayish-beige
Storage Condition	Room Temprature

19968-85-5 - Risk and Safety

Safety Description	24/25 - Avoid contact with skin and eyes.
WGK Germany	3
HS Code	29221985

19968-85-5 - Reference Information

uses

pharmaceutical intermediates for the production of guanethidine.

Production method

First, cyclohexanone and nitromethane are added, and then reduced with iron powder. Add methanol, nitromethane and cyclohexanone into the reaction tank, stir, control the temperature at 5-10 ℃, add sodium hydroxide solution dropwise, finish adding, cool to -4 ℃, stir for 1h, centrifuge and filter. The filtrate recovers methanol, the filter cake is dissolved in water, acidified with acetic acid to pH4-5 at 10 ℃, heated to 30 ℃ to completely dissolve, and the oil layer is divided to obtain nitromethylcyclohexanol. When the reduction operation is carried out, water, iron powder and 2/3 hydrochloric acid in the total amount are first added to the reaction tank, the pH5-6 is controlled, the temperature is 40-50 ℃, the crude nitromethylcyclohexanol oil is obtained by dropping one step, and the temperature is kept and stirred after adding, add 1/6 hydrochloric acid every 1 hour, add 1/3 of the total hydrochloric acid in 2 times, maintain pH5-6, continue stirring for 2 hours, and then filter while hot. The filtrate is amine methylcyclohexanol salt solution.

Last Update：2024-04-09 20:52:54