1H-Indol-7-ylacetonitrile
1H-indol-7-ylacetonitrile
CAS: 82199-98-2
Molecular Formula: C10H8N2
1H-Indol-7-ylacetonitrile - Names and Identifiers
| Name | 1H-indol-7-ylacetonitrile |
| Synonyms | 82199-98-2 7-(Cyanomethyl)indole 1H-Indole-7-acetonitrile 1H-Indole,7-acetonitrile 1H-indol-7-ylacetonitrile 1H-Indol-7-ylacetonitrile 7-(Cyanomethyl)-1H-indole 1H-Indole-7-acetonitrile(9CI) 2-(1H-indol-7-yl)acetonitrile |
| CAS | 82199-98-2 |
| InChI | InChI=1/C10H8N2/c11-6-4-8-2-1-3-9-5-7-12-10(8)9/h1-3,5,7,12H,4H2 |
1H-Indol-7-ylacetonitrile - Physico-chemical Properties
| Molecular Formula | C10H8N2 |
| Molar Mass | 156.18 |
| Density | 1.219g/cm3 |
| Boling Point | 374.108°C at 760 mmHg |
| Flash Point | 127.557°C |
| Vapor Presure | 0mmHg at 25°C |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.673 |
1H-Indol-7-ylacetonitrile - Introduction
1H-indol-7-ylacetonitrile is an organic compound with the chemical formula C10H8N2. The following is a detailed description of the properties, uses, preparation and safety information of the compound:
Nature:
1H-indol-7-ylacetonitrile is an organic compound with an indole ring and a nitrile group. It is a solid, white to pale yellow crystalline. The compound is stable at ambient temperature and can be dissolved in organic solvents such as chloroform and dimethyl sulfoxide. Its melting point is about 146-150°C.
Use:
1H-indol-7-ylacetonitrile is widely used in the field of medicine. It is an important intermediate compound and is often used as a starting material for the synthesis of indole compounds in organic synthesis. Indole compounds have a wide range of applications in drug development, such as the synthesis of anticancer drugs and neurotransmitters.
Preparation Method:
1H-indol-7-ylacetonitrile has many preparation methods, and the common method is obtained by the reaction of indole and bromoacetonitrile. The specific step is to dissolve the indole in an organic solvent, then add an excess of bromoacetonitrile, and add a base catalyst. After the reaction has been carried out for a period of time, the product can be purified by crystallization or column chromatography.
Safety Information:
1H-indol-7-ylacetonitrile as an organic compound, need to pay attention to safe operation. Avoid inhaling its dust or vapors, and avoid contact with skin and eyes when exposed to this compound. Wear appropriate personal protective equipment such as lab gloves and goggles during use and handling. In addition, the operation should be carried out in a well-ventilated laboratory environment.
Nature:
1H-indol-7-ylacetonitrile is an organic compound with an indole ring and a nitrile group. It is a solid, white to pale yellow crystalline. The compound is stable at ambient temperature and can be dissolved in organic solvents such as chloroform and dimethyl sulfoxide. Its melting point is about 146-150°C.
Use:
1H-indol-7-ylacetonitrile is widely used in the field of medicine. It is an important intermediate compound and is often used as a starting material for the synthesis of indole compounds in organic synthesis. Indole compounds have a wide range of applications in drug development, such as the synthesis of anticancer drugs and neurotransmitters.
Preparation Method:
1H-indol-7-ylacetonitrile has many preparation methods, and the common method is obtained by the reaction of indole and bromoacetonitrile. The specific step is to dissolve the indole in an organic solvent, then add an excess of bromoacetonitrile, and add a base catalyst. After the reaction has been carried out for a period of time, the product can be purified by crystallization or column chromatography.
Safety Information:
1H-indol-7-ylacetonitrile as an organic compound, need to pay attention to safe operation. Avoid inhaling its dust or vapors, and avoid contact with skin and eyes when exposed to this compound. Wear appropriate personal protective equipment such as lab gloves and goggles during use and handling. In addition, the operation should be carried out in a well-ventilated laboratory environment.
Last Update：2024-04-09 20:52:54
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