1H-Purin-6-amine
Adenine
CAS: 73-24-5
Molecular Formula: C5H5N5
1H-Purin-6-amine - Names and Identifiers
| Name | Adenine |
| Synonyms | A Ade Adenin Adenine Leuco-4 usafcb-18 USAF CB-18 Vitamin B4 Adeninimine 6-Aminopurine 5H-purin-6-amine Purine, 6-amino- 1H-Purin-6-amine vitaminb4(adenine) ADENINE FREE BASE PLANT TISSUE CULTURETE STED |
| CAS | 73-24-5 |
| EINECS | 200-796-1 |
| InChI | InChI=1/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-3H,(H2,6,7,8,9,10) |
| InChIKey | GFFGJBXGBJISGV-UHFFFAOYSA-N |
1H-Purin-6-amine - Physico-chemical Properties
| Molecular Formula | C5H5N5 |
| Molar Mass | 135.13 |
| Density | 1.3795 (rough estimate) |
| Melting Point | >360 °C (lit.) |
| Boling Point | 238.81°C (rough estimate) |
| Flash Point | 220°C |
| Water Solubility | 0.5 g/L (20 ºC) |
| Solubility | Insoluble in cold water, soluble in boiling water, acid and alkali, slightly soluble in ethanol, insoluble in ether and chloroform |
| Vapor Presure | 0.00172mmHg at 25°C |
| Appearance | White crystalline powder |
| Color | Clear colorless to light yellow |
| Odor | Odorless |
| Merck | 14,152 |
| BRN | 5777 |
| pKa | 4.12(at 25℃) |
| Storage Condition | 2-8°C |
| Stability | Stable. Moisture-sensitive. Incompatible with strong oxidizing agents. |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.7000 (estimate) |
| MDL | MFCD00041790 |
| Physical and Chemical Properties | Character white fine powder crystal, with strong salty taste. Melting Point: 360~365 ℃ solubility: insoluble in cold water, soluble in boiling water, acid and alkali, slightly soluble in ethanol, insoluble in ether and chloroform. |
| Use | For the production of adenosine, ATP, ADP, anti-AIDS drugs and Vitamin B4 and plant growth hormone 6-benzyl adenine |
1H-Purin-6-amine - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | AU6125000 |
| FLUKA BRAND F CODES | 8-10-23 |
| TSCA | Yes |
| HS Code | 29335990 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 orally in rats: 745 mg/kg (Philips) |
1H-Purin-6-amine - Nature
Open Data Verified Data
White fine powder crystals with strong salty taste. Insoluble in cold water, soluble in boiling water, acid and alkali, ethanol-soluble, insoluble in ether and chloroform. The aqueous solution was neutral. Melting point 360-365 °c (simultaneous decomposition) sublimation begins at 220 °c.
Last Update：2024-01-02 23:10:35
1H-Purin-6-amine - Preparation Method
Open Data Verified Data
malonic acid Diethyl ester and formamide, sodium ethoxide condensation of 4,6 dihydroxy pyrimidine, and then nitric acid and sulfuric acid nitration of 4,6 = hydroxy 5 Nitro pyrimidine, 4,6-dichloro-5-nitropyrimidine was prepared by chlorination of phosphorus oxychloride in triethylamine solution and then ammoniated with ammonia.
4,6-= amino -5-nitropyrimidine. 4,6-= amino-5-nitropyrimidine, formic acid, formamide and sodium thiosulfate are cyclized together to form 6-aminopurine.
Last Update：2022-01-01 10:54:01
1H-Purin-6-amine - Standard
Authoritative Data Verified Data
This product is 7h-purin-6-amine. Calculated as dried product, containing no less than 98.5% of C5H5N5.
Last Update：2024-01-02 23:10:35
1H-Purin-6-amine - Trait
Authoritative Data Verified Data
- This product is white or off-white powder or crystalline or crystalline powder, odorless and tasteless.
- This product is slightly soluble in hot water, slightly soluble in ethanol, and slightly soluble in water.
Last Update：2022-01-01 11:27:27
1H-Purin-6-amine - Use
Open Data Verified Data
used in medicine and biological research, such as purine drug synthesis and microbiological method for the determination of nicotinic acid.
Last Update：2022-01-01 10:54:00
1H-Purin-6-amine - Differential diagnosis
Authoritative Data Verified Data
- This product was dissolved and diluted with dilute acetic acid to prepare a solution containing 1 mg per 1 ml as a test solution. Adenine control, the same method to make the control solution. Take 10mg of adenine and 10mg of vidarabine control, put them in a 10ml measuring flask, dissolve them in dilute acetic acid (heat if necessary) and dilute them to the scale as a system-suitable solution. According to the thin layer chromatography (General 0502) test, draw 5ul of each of the above solutions, put them on the same silica gel GF2S4 thin layer plate, and use concentrated ammonia-ethyl acetate-propanol (20 : 40 : 40) as the developing solvent, expand, dry, set the UV lamp (254nm) to view, the system applicable solution should have two clear and separated spots, the position and color of the main spot displayed by the test solution should be the same as the position and color of the main spot of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the reference product (General rule 0402).
Last Update：2022-01-01 11:27:27
1H-Purin-6-amine - Safety
Open Data Verified Data
- toxic, rats oral LD50 745mg/kg. The production workshop should be well ventilated, the equipment should be sealed, and the operator should wear protective equipment.
- the iron drum is packed with polyethylene plastic bags. Store in a cool, ventilated, dry place. Protection against heat, moisture and sun. According to the provisions of the storage and transportation of toxic chemicals.
Last Update：2022-01-01 10:54:01
1H-Purin-6-amine - Exam
Authoritative Data Verified Data
pH
take 2.5g of this product, add 50ml of water, boil for 3 minutes, let cool, add water to make up to 50ml, filter, take 10ml of filtrate (the remaining filtrate is ready for use), add bromothymol blue indicator 0.lml and 0.Olmol/L sodium hydroxide solution 0.2ml, the solution is blue, plus 0.01mol/L hydrochloric acid solution 0.4ml, the solution is yellow.
clarity and color of solution
take 0901G of this product, add 50ml of dilute hydrochloric acid to dissolve, check according to law (General rule 0902 and general rule), the solution should be clear and colorless.
chloride
take 0.5g of this product, first burn with small fire to charring, then burn at 500~600°C to Ash completely, let it cool, and check according to law (General rule 0801), not more concentrated (0.01%) than the control solution made from of standard sodium chloride solution.
sulfate
Take 10ml of the filtrate under the pH value and check it according to the law (General rule 0802). Compared with the control solution made of 0.03% of standard potassium sulfate solution, it should not be more concentrated ().
organic impurities
preparation of reference solution the appropriate amount of adenine reference was accurately weighed, heated with an appropriate amount of water to dissolve, allowed to cool, and quantitatively diluted with water to make a solution containing about 0.19mg per 1 ml, respectively, take 3ml into three 100ml measuring bottles, respectively, with O. 1 mol/L hydrochloric acid solution, O. 1 mol/L sodium hydroxide solution, pH 7.0 phosphate buffer [take potassium dihydrogen phosphate 4.54g, dissolve with water and dilute to 500ml, as A solution; Take anhydrous disodium hydrogen phosphate 4.73g, dissolve with water and dilute to 500ml, as B solution. Take 38.9ml of the above solution A and 61.1 ml of the solution B, and shake it well to obtain (if necessary, add the human solution B Dropwise to bring the pH value of the solution to 7.0 )] diluted to the scale, and shake it well.
nitrogen content
take this product about 50mg, precision weighing, inspection according to law (General rule 0704 The first method), according to the dry product calculation, nitrogen content should be 50.2% ~ 53.4%.
loss on drying
Take lg of this product, dry to constant weight at 105°C, and lose no more than 0.5% of weight (General rule 0831).
ignition residue
lg of this product shall be taken for inspection according to law (General rule 0841), and the remaining residue shall not exceed 0.1%.
ammonium salt
Take 2g of this product and check it according to law (General rule 0808). Compared with the standard ammonium chloride solution of 2.0 ml, the control solution made by the same method should not be more concentrated (0.001%).
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
Last Update：2022-01-01 11:27:28
1H-Purin-6-amine - Content determination
Authoritative Data Verified Data
take the product O.lg, precision weighing, add acetic anhydride 20ml and anhydrous acetic acid 30ml dissolved. According to the potentiometric titration method (General 0701), with perchloric acid titration solution (O.lmol/L) titration to the end point. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 13.51mg of C5H5Ns.
Last Update：2022-01-01 11:27:29
1H-Purin-6-amine - Category
Authoritative Data Verified Data
pharmaceutical excipients, lyoprotectants, etc.
Last Update：2022-01-01 11:27:29
1H-Purin-6-amine - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:27:29
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