1H-Pyrazole,3-(4-fluorophenyl)-(9CI)

1H-Pyrazole,3-(4-fluorophenyl)-(9CI) - Names and Identifiers

Name	3-(4-Fluorophenyl)-1H-pyrazole
Synonyms	AKOS B028619 BUTTPARK 157-51 ART-CHEM-BB B028619 TIMTEC-BB SBB000139 3-(4-FLUOROPHENYL)PYRAZOLE 3-(4-Fluorophenyl)-1H-pyrazole 5-(4-fluorophenyl)-1H-pyrazole 5-(4-FLUOROPHENYL)-1H-PYRAZOLE 3-(4-FLUORO-PHENYL)-1 H-PYRAZOLE 1H-Pyrazole,3-(4-fluorophenyl)-(9CI)
CAS	154258-82-9
InChI	InChI=1/C9H7FN2/c10-8-3-1-7(2-4-8)9-5-6-11-12-9/h1-6H,(H,11,12)

1H-Pyrazole,3-(4-fluorophenyl)-(9CI) - Physico-chemical Properties

Molecular Formula	C9H7FN2
Molar Mass	162.16
Density	1.242±0.06 g/cm3(Predicted)
Melting Point	100-104 °C
Boling Point	334.1±17.0 °C(Predicted)
Flash Point	155.8°C
Vapor Presure	0.000254mmHg at 25°C
pKa	13.04±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.579

1H-Pyrazole,3-(4-fluorophenyl)-(9CI) - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection.
WGK Germany	3
Hazard Class	IRRITANT

1H-Pyrazole,3-(4-fluorophenyl)-(9CI) - Introduction

3-(4-Fluorophenyl)-1H-pyrazole is an organic compound with the chemical formula C9H6FN3. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 3-(4-Fluorophenyl)-1H-pyrazole is a colorless crystalline solid.
-Melting point: approximately 113-116°C.
-Solubility: It can be dissolved in some organic solvents, such as dimethyl sulfoxide and dichloromethane.

Use:
- 3-(4-Fluorophenyl)-1H-pyrazole is an important organic synthesis intermediate that can be used to synthesize other organic compounds.
-It is used as a precursor of anti-inflammatory drugs in the field of medicine.

Method:
The preparation of 3-(4-Fluorophenyl)-1H-pyrazole usually involves the following steps:
1. First, aniline and alkaline carbonate are reacted to generate aniline salt.
2. Then, the aniline salt is reacted with a fluorinating agent to introduce a fluorine atom.
3. Finally, the resulting compound is reacted with pyrazole to produce the final product.

Safety Information:
- 3-(4-Fluorophenyl)-1H-pyrazole is an organic compound, so it has certain toxicity and danger. Use should follow the relevant laboratory safety procedures, take appropriate protective measures.
-Gases, vapors and solutions can cause irritation and damage to the eyes, skin and respiratory tract, so avoid contact with this compound.
-Store it in a dry, sealed container, away from fire and heat.

Last Update：2024-04-09 21:01:54