1H-indazole-4-carbonitrile
1H-indazole-4-carbonitrile
CAS: 861340-10-5
Molecular Formula: C8H5N3
1H-indazole-4-carbonitrile - Names and Identifiers
| Name | 1H-indazole-4-carbonitrile |
| Synonyms | 4-Indazolenitrile 4-CYANO (1H)INDAZOLE 1H-indazole-4-carbonitrile |
| CAS | 861340-10-5 |
| InChI | InChI=1/C8H5N3/c9-4-6-2-1-3-8-7(6)5-10-11-8/h1-3,5H,(H,10,11) |
1H-indazole-4-carbonitrile - Physico-chemical Properties
| Molecular Formula | C8H5N3 |
| Molar Mass | 143.15 |
| Density | 1.33±0.1 g/cm3(Predicted) |
| Melting Point | 157-160 °C(Solv: ligroine (8032-32-4)) |
| Boling Point | 370.3±15.0 °C(Predicted) |
| Flash Point | 126.7°C |
| Vapor Presure | 1.12E-05mmHg at 25°C |
| pKa | 11.61±0.40(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Refractive Index | 1.684 |
1H-indazole-4-carbonitrile - Introduction
1H-indazole-4-carbonitrile is an organic compound containing an indazole ring and a nitrile group. Its chemical formula is C7H4N2 and its relative molecular mass is 132.12g/mol.
Nature:
1H-indazole-4-carbonitrile is a white to pale yellow crystalline solid, soluble in organic solvents such as ethanol and dimethylformamide, insoluble in water. It is stable at room temperature and decomposes at high temperatures.
Use:
1H-indazole-4-carbonitril is a commonly used organic synthesis intermediate, which can be used to synthesize a variety of functionalized indazole derivatives. It has a wide range of applications in the field of medicine, can be used for the synthesis of anti-tumor, anti-inflammatory, antibacterial drugs. In addition, it can also be used for the synthesis of photoelectric materials, dyes and pesticides.
Preparation Method:
There are many synthetic methods of 1H-indazole-4-carbonitrile, and the commonly used method is obtained by the reaction of indazole with potassium cyanide. The specific steps are as follows:
1. Dissolve the indazole in an appropriate amount of anhydrous solvent, such as dimethylformamide.
2. Add potassium cyanide suspension at low temperature and stir for a period of time.
3. adjust the acidity in the solvent to make the pH value of the reaction system close to neutral.
4. Filtration gives a pale yellow solid, which can be dried to give 1H-indazole-4-carbonitril product.
Safety Information:
1H-indazole-4-carbonitril is safer for humans under normal operating conditions. However, as a chemical substance, attention should be paid to its toxicity and irritation. During the operation, appropriate laboratory safety measures should be taken, such as wearing protective glasses, chemical protective clothing and gloves, avoiding inhalation of its aerosol or solution spray, and avoiding skin contact. During storage and handling, keep away from ignition and oxidizing agents, and follow appropriate safety procedures.
Nature:
1H-indazole-4-carbonitrile is a white to pale yellow crystalline solid, soluble in organic solvents such as ethanol and dimethylformamide, insoluble in water. It is stable at room temperature and decomposes at high temperatures.
Use:
1H-indazole-4-carbonitril is a commonly used organic synthesis intermediate, which can be used to synthesize a variety of functionalized indazole derivatives. It has a wide range of applications in the field of medicine, can be used for the synthesis of anti-tumor, anti-inflammatory, antibacterial drugs. In addition, it can also be used for the synthesis of photoelectric materials, dyes and pesticides.
Preparation Method:
There are many synthetic methods of 1H-indazole-4-carbonitrile, and the commonly used method is obtained by the reaction of indazole with potassium cyanide. The specific steps are as follows:
1. Dissolve the indazole in an appropriate amount of anhydrous solvent, such as dimethylformamide.
2. Add potassium cyanide suspension at low temperature and stir for a period of time.
3. adjust the acidity in the solvent to make the pH value of the reaction system close to neutral.
4. Filtration gives a pale yellow solid, which can be dried to give 1H-indazole-4-carbonitril product.
Safety Information:
1H-indazole-4-carbonitril is safer for humans under normal operating conditions. However, as a chemical substance, attention should be paid to its toxicity and irritation. During the operation, appropriate laboratory safety measures should be taken, such as wearing protective glasses, chemical protective clothing and gloves, avoiding inhalation of its aerosol or solution spray, and avoiding skin contact. During storage and handling, keep away from ignition and oxidizing agents, and follow appropriate safety procedures.
Last Update：2024-04-09 20:52:54
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CAS: 861340-10-5
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Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 861340-10-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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