1H-indazole-5-carbaldehyd...
1H-indazole-5-carbaldehyde
CAS: 253801-04-6
Molecular Formula: C8H6N2O
1H-indazole-5-carbaldehyd... - Names and Identifiers
| Name | 1H-indazole-5-carbaldehyde |
| Synonyms | LogP 5-FORMYL INDAZOLE 1H-indazole-5-carbaldehyde 1H-INDAZOLE-5-CARBALDEHYDE 1H-indazole-5-carbaldehyd... 1H-Indazole-5-carboxaldehyde 1H-Indazole-5-carboxaldehyde (9CI) 6-[(4-nitrophenyl)hydrazono]hexane-1,2,3,4,5-pentol 6-[(4-nitrophenyl)hydrazinylidene]hexane-1,2,3,4,5-pentol |
| CAS | 253801-04-6 |
| InChI | InChI=1/C8H6N2O/c11-5-6-1-2-8-7(3-6)4-9-10-8/h1-5H,(H,9,10) |
1H-indazole-5-carbaldehyd... - Physico-chemical Properties
| Molecular Formula | C8H6N2O |
| Molar Mass | 146.15 |
| Density | 1.368±0.06 g/cm3(Predicted) |
| Melting Point | 115-119°C |
| Boling Point | 358.3±15.0 °C(Predicted) |
| Flash Point | 174.4°C |
| Vapor Presure | 2.56E-05mmHg at 25°C |
| pKa | 12.87±0.40(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.747 |
1H-indazole-5-carbaldehyd... - Risk and Safety
| WGK Germany | 3 |
1H-indazole-5-carbaldehyd... - Reference Information
| introduction | 1H-indazole -5-formaldehyde is indazole derivatives, which have various biological activities, such as anti-inflammatory, anti-tumor, antioxidant, hypoglycemic, anti-HIV, anti-tuberculosis, anti-platelet, 5-HT3 receptor antagonism, etc. |
| preparation | in a 100mL three-neck bottle, add 7.0mL N,N-dimethylformamide, cool to 0~5 ℃, slowly add 1.0mL phosphorus oxychloride dropwise, finish dropwise, continue stirring for 20min, add 1.9g(10mmol) 5-bromoindazole dropwise below 10 ℃ and dissolve in 3.0mL N, the solution of N-dimethylformamide is dropped and reacted at 35 ℃ for 1h. Add 10mL of water under the cooling of ice water, adjust the pH value to neutral with 15% hydroxide, then reflux 20min, cool to obtain yellow solid, and purify the target compound 1H-indazole -5-formaldehyde by silica gel column chromatography. |
Last Update：2024-04-10 22:29:15
