1β-hydroxybaccatinI
1-Hydroxybaccatin I
CAS: 30244-37-2
Molecular Formula: C32H44O14
1β-hydroxybaccatinI - Names and Identifiers
| Name | 1-Hydroxybaccatin I |
| Synonyms | Nsc330755 1- hydroxybacatin I 1-Hydroxybaccatin I 1β-hydroxybaccatinI 1-HYDROXYBACCATIN I HYDROXYBACCATIN I, 1-(RG) [1S,4R,(+)]-4,20-Epoxytax-11-ene-1,2α,5α,7β,9α,10β,13α-heptol 2,5,7,9,10,13-hexaacetate Spiro[6,10-methanobenzocyclodecene-4(6H),2'-oxirane]-1,3,5,6,8,11,12-heptol, 1,2,3,4a,5,7,8,11,12,12a-decahydro-9,12a,13,13-tetramethyl-, 1,3,5,8,11,12-hexaacetate, (1S,2'R,3S,4aR,5S,6S,8S,11R,12R,12aS)- (9CI) |
| CAS | 30244-37-2 |
1β-hydroxybaccatinI - Physico-chemical Properties
| Molecular Formula | C32H44O14 |
| Molar Mass | 652.68 |
| Density | 1.31±0.1 g/cm3(Predicted) |
| Melting Point | 260-261 °C |
| Boling Point | 657.2±55.0 °C(Predicted) |
| Specific Rotation(α) | 102 |
| pKa | 12.68±0.70(Predicted) |
| Storage Condition | 2-8℃ |
1β-hydroxybaccatinI - Introduction
1-Hydroxybaccatin I (1-hydroxybacatin I) is a natural compound extracted from the spruce genus, also known as bacatin I. Its chemical structure contains a hydroxyl functional group.
Nature:
-Appearance: 1-Hydroxybaccatin I is a colorless or slightly yellow crystalline powder.
-Melting point: Its melting point range is usually between 185-190°C.
-Solubility: It is soluble in ethanol, dimethyl sulfoxide and dichloromethane, but less soluble in water.
Use:
-Pharmaceutical preparation: 1-Hydroxybaccatin I is an important intermediate of Paclitaxel, a natural source. Paclitaxel is a drug widely used in anti-cancer therapy, especially for breast cancer, ovarian cancer and lung cancer.
-Chemical synthesis: 1-Hydroxybaccatin I can be used as an important starting material for the synthesis of other similar compounds, such as semi-synthetic paclitaxel derivatives.
Method:
1-Hydroxybaccatin I is usually obtained by extraction and isolation from spruce plants. The extract can be purified by column chromatography, liquid-liquid partitioning or other separation techniques.
Safety Information:
The safety information of 1-Hydroxybaccatin I is limited, but it can be handled according to relevant laboratory operating procedures and safety guidelines. As an ingredient in plant extracts, there may be some potential risks associated with industrial use, so appropriate safety measures should be taken when using them. Specific safety assessment and risk management should be carried out according to the actual application. In laboratory and industrial environments, standard operating procedures such as the use of personal protective equipment and proper ventilation must be adopted.
Nature:
-Appearance: 1-Hydroxybaccatin I is a colorless or slightly yellow crystalline powder.
-Melting point: Its melting point range is usually between 185-190°C.
-Solubility: It is soluble in ethanol, dimethyl sulfoxide and dichloromethane, but less soluble in water.
Use:
-Pharmaceutical preparation: 1-Hydroxybaccatin I is an important intermediate of Paclitaxel, a natural source. Paclitaxel is a drug widely used in anti-cancer therapy, especially for breast cancer, ovarian cancer and lung cancer.
-Chemical synthesis: 1-Hydroxybaccatin I can be used as an important starting material for the synthesis of other similar compounds, such as semi-synthetic paclitaxel derivatives.
Method:
1-Hydroxybaccatin I is usually obtained by extraction and isolation from spruce plants. The extract can be purified by column chromatography, liquid-liquid partitioning or other separation techniques.
Safety Information:
The safety information of 1-Hydroxybaccatin I is limited, but it can be handled according to relevant laboratory operating procedures and safety guidelines. As an ingredient in plant extracts, there may be some potential risks associated with industrial use, so appropriate safety measures should be taken when using them. Specific safety assessment and risk management should be carried out according to the actual application. In laboratory and industrial environments, standard operating procedures such as the use of personal protective equipment and proper ventilation must be adopted.
Last Update：2024-04-09 20:49:11
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CAS: 30244-37-2
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Email: 2853786052@qq.com
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QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: 1-Hydroxybaccatin I Visit Supplier Webpage Request for quotationCAS: 30244-37-2
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