2 AMINO 4 METHYL PYRIDINE AMINO PYRIDIN E
HMN-154
CAS: 173528-92-2
Molecular Formula: C20H18N2O3S
2 AMINO 4 METHYL PYRIDINE AMINO PYRIDIN E - Names and Identifiers
2 AMINO 4 METHYL PYRIDINE AMINO PYRIDIN E - Physico-chemical Properties
| Molecular Formula | C20H18N2O3S |
| Molar Mass | 366.43 |
| Density | 1.313±0.06 g/cm3(Predicted) |
| Boling Point | 553.7±60.0 °C(Predicted) |
| Solubility | DMSO: ≥15 mg/mL |
| pKa | 8.09±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| In vitro study | HMN-154 interacts with NF-YB and thereby interrupts the binding of the NF-Y heterotrimer to DNA. NF-YB and thymosin β-10 are specific cellular binding proteins of HMN-154 and that this shared region is necessary for the binding to HMN-154. HMN-154 inhibits DNA binding of NF-Y to the human major histocompatibility complex class II human leukocyte antigen DRA Y-box sequence in a dose-dependent manner. HMN-154 shows very strong cytotoxicity against KB and colon38 cells with an IC 50 value of 0.0026 and 0.003 μg/mL, respectively. HMN-154/BSA binds recombinant NF-YB or thymosin β-10 and the binding is inhibited by the addition of HMN-154 as the competitor. The binding between HMN-154 and NF-YB is specific and depends on its cytotoxicity. |
2 AMINO 4 METHYL PYRIDINE AMINO PYRIDIN E - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.729 ml | 13.645 ml | 27.29 ml |
| 5 mM | 0.546 ml | 2.729 ml | 5.458 ml |
| 10 mM | 0.273 ml | 1.365 ml | 2.729 ml |
| 5 mM | 0.055 ml | 0.273 ml | 0.546 ml |
Last Update：2024-01-02 23:10:35
2 AMINO 4 METHYL PYRIDINE AMINO PYRIDIN E - Reference Information
| biological activity | HMN-154 is a novel benzenesulfonamide anticancer compound. HMN-154 interacts with NF-YB, interrupting the binding of the NF-Y heterotrimer to DNA. |
| Target | IC50: 0.0026 μg/mL (KB cells), 0.003 μg/mL (colon38 cells) |
Last Update：2024-04-09 02:00:14
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CAS: 173528-92-2
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Email: 3008007409@qq.com
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CAS: 173528-92-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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