HMN154

Name	HMN-154
Synonyms	HMN154 HMN 154 HMN-154 2 AMINO 4 METHYL PYRIDINE AMINO PYRIDIN E (E)-4-[2-{2-[N-(4-Methoxybenzenesulfonyl)aMino]phenyl}ethenyl ]pyridine Benzenesulfonamide, 4-methoxy-N-[2-[(1E)-2-(4-pyridinyl)ethenyl]phenyl]-
CAS	173528-92-2

Molecular Formula	C20H18N2O3S
Molar Mass	366.43
Density	1.313±0.06 g/cm3(Predicted)
Boling Point	553.7±60.0 °C(Predicted)
Solubility	DMSO: ≥15 mg/mL
pKa	8.09±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
In vitro study	HMN-154 interacts with NF-YB and thereby interrupts the binding of the NF-Y heterotrimer to DNA. NF-YB and thymosin β-10 are specific cellular binding proteins of HMN-154 and that this shared region is necessary for the binding to HMN-154. HMN-154 inhibits DNA binding of NF-Y to the human major histocompatibility complex class II human leukocyte antigen DRA Y-box sequence in a dose-dependent manner. HMN-154 shows very strong cytotoxicity against KB and colon38 cells with an IC 50 value of 0.0026 and 0.003 μg/mL, respectively. HMN-154/BSA binds recombinant NF-YB or thymosin β-10 and the binding is inhibited by the addition of HMN-154 as the competitor. The binding between HMN-154 and NF-YB is specific and depends on its cytotoxicity.

Last Update：2024-01-02 23:10:35

biological activity	HMN-154 is a novel benzenesulfonamide anticancer compound. HMN-154 interacts with NF-YB, interrupting the binding of the NF-Y heterotrimer to DNA.
Target	IC50: 0.0026 μg/mL (KB cells), 0.003 μg/mL (colon38 cells)

Last Update：2024-04-09 02:00:14

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Product Name: HMN-154 Visit Supplier Webpage Request for quotation
CAS: 173528-92-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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HMN154

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