2,2,2-trichloro-1-(1-methyl-1H-imidazol-2-yl)ethanone

2,2,2-trichloro-1-(1-methyl-1H-imidazol-2-yl)ethanone - Names and Identifiers

Name	2,2,2-trichloro-1-(1-methyl-1H-imidazol-2-yl)ethan-1-one
Synonyms	1-Methyl-2-(trichloroacetyl)imidazole 1-Methyl-2-(trichloroacetyl)-1H-imidazole 2,2,2-trichloro-1-(1-methyl-1H-imidazol-2-yl)ethanone 2,2,2-trichloro-1-(1-methyl-1H-imidazol-2-yl)ethan-1-one Ethanone, 2,2,2-trichloro-1-(1-methyl-1H-imidazol-2-yl)-
CAS	30148-23-3

2,2,2-trichloro-1-(1-methyl-1H-imidazol-2-yl)ethanone - Physico-chemical Properties

Molecular Formula	C6H5Cl3N2O
Molar Mass	227.48
Density	1.56±0.1 g/cm3(Predicted)
Melting Point	83-84 °C
Boling Point	272.3±50.0 °C(Predicted)
Solubility	Chloroform (Slightly), Methanol (Slightly)
Appearance	Solid
Color	Pale Beige to Beige
pKa	2.17±0.25(Predicted)
Storage Condition	Amber Vial, -20°C Freezer, Under inert atmosphere
Stability	Light Sensitive, Moisture Sensitive

2,2,2-trichloro-1-(1-methyl-1H-imidazol-2-yl)ethanone - Reference Information

Use

1-methyl-2-trichloroacetylimidazole is an organic intermediate, which can be obtained by one-step reaction of trichloroacetyl chloride and N-methylimidazole. It has been reported that it can be used to prepare C- 2 substituted imidazole chiral ionic liquids.

preparation

synthesis of 1-methyl -2-trichloroacetyl imidazole: under the protection of nitrogen, add
7mL(11.2g,61mmol) trichloroacetyl chloride and 40 mLCH2Cl2 into a 100mL three-mouth bottle. Fill 5mL(5.00g, 63mmol)1-methylimidazole and 30mL

CH2Cl2 in a constant pressure funnel, slowly drop into a three-mouth bottle, add the drops for about 2 hours, and continue stirring at room temperature for 8 hours. The reaction mixture was cooled to 0°C in an ice water bath, 8.8mL triethylamine was added dropwise, and stirred for another 1h. Filtration, the filtrate is reduced pressure to remove the solvent, and recrystallized (n-hexane is used as solvent) to obtain 9.43g of white crystals with 68% yield. Mp76 ℃ ~ 77 ℃. MS(EI)m/z
226 (m, the theoretical value of the C6H5N2OCl3 is 226).

Last Update：2024-04-09 21:01:54