2,2,2-trifluoro-1-(4-hydroxyphenyl)ethan-1-one

2,2,2-trifluoro-1-(4-hydroxyphenyl)ethan-1-one - Names and Identifiers

Name	2,2,2-trifluoro-1-(4-hydroxyphenyl)ethanone
Synonyms	4-(Trifluoroacetyl)phenol 4'-Hydroxy-2,2,2-trifluoroacetophenone 3-(1-amino-2,2,2-trifluoroethyl)phenol 2,2,2-Trifluoro-4'-hydroxyacetophenone 2,2,2-Trifluoro-1-(4-hydroxyphenyl)ethanone 2,2,2-trifluoro-1-(4-hydroxyphenyl)ethanone 2,2,2-TRIFLUORO-1-(4-HYDROXY-PHENYL)-ETHANONE _x000D_2,2,2-Trifluoro-4'-hydroxyacetophenone 2,2,2-trifluoro-1-(4-hydroxyphenyl)ethan-1-one ethanone, 2,2,2-trifluoro-1-(4-hydroxyphenyl)- Ethanone, 2,2,2-trifluoro-1-(4-hydroxyphenyl)-
CAS	1823-63-8
InChI	InChI=1/C8H5F3O2/c9-8(10,11)7(13)5-1-3-6(12)4-2-5/h1-4,12H

2,2,2-trifluoro-1-(4-hydroxyphenyl)ethan-1-one - Physico-chemical Properties

Molecular Formula	C8H5F3O2
Molar Mass	190.12
Density	1.400±0.06 g/cm3(Predicted)
Melting Point	114 °C
Boling Point	261.9±35.0 °C(Predicted)
Flash Point	112.2°C
Vapor Presure	0.007mmHg at 25°C
pKa	7.60±0.13(Predicted)
Storage Condition	2-8°C
Refractive Index	1.481

2,2,2-trifluoro-1-(4-hydroxyphenyl)ethan-1-one - Introduction

2,2,2-trifluoro-1-(4-hydroxyphenyl)ethanone, also known as TFHA, is an organic compound. The following is an introduction to its nature, use, preparation and safety information:

Nature:
-Appearance: TFHA is a colorless liquid or light yellow oily substance.
-Solubility: It dissolves in many organic solvents, such as ethanol, ether and chloroform.
-Melting point: The melting point of TFHA is 25-27 degrees Celsius.
-Boiling point: Its boiling point is 185-190 degrees Celsius.

Use:
-Chemical synthesis: TFHA can be used as a reagent or catalyst in organic synthesis, and is widely used in the fields of dyes, drugs, medicine and pesticides.
-Reaction medium: Due to its unique properties, TFHA can be used as a non-polar medium and as a solvent and catalyst in some specific organic reactions.
-Flame retardant: The fluorine atom and benzene ring structure of TFHA give it excellent flame retardant properties, so it can also be used as one of the components of flame retardant.

Method:
The preparation method of TFHA includes:
-First prepare substituted benzoic acid:
1. 4-hydroxybenzoic acid and glacial acetic acid are heated to react to generate p-Hydroxybenzoic acid.
2. Add sodium bicarbonate to neutralize the reaction solution.
-Reprepare 2,2,2-trifluoro-1-(4-hydroxyphenyl)ethanone:
Trifluoroacetic anhydride was added to the reaction solution of p-Hydroxybenzoic acid, followed by stirring, and an increase in the temperature of the reaction solution was observed. After completion of the reaction, TFHA was obtained by distillation extraction. The preparation process requires control of parameters such as temperature and reaction time.

Safety Information:
- TFHA is an organofluorine compound that can cause irritation and burns to the skin, eyes and respiratory tract.
-Wear protective gloves, safety glasses and respiratory protection when using.
-Avoid contact with oxidants, strong acids and alkalis.

Last Update：2024-04-09 21:04:16