2,2-difluoro-2-(4-(trifluoromethoxy)phenyl)ethan-1-ol - Names and Identifiers
2,2-difluoro-2-(4-(trifluoromethoxy)phenyl)ethan-1-ol - Introduction
2,2-difluoro-2-(4-(trifluoromethoxy)phenyl)ethanol is an organic compound with the formula C10H9F5O2. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: colorless liquid
-Boiling Point: 195-196 ° C
-Density: 1.42 g/mL
-Solubility: Soluble in organic solvents such as ether, ethanol and chloroform
Use:
- 2,2-difluoro-2-(4-(trifluoromethoxy)phenyl)ethanol is commonly used as a reagent in organic synthesis and is used in the synthesis of other organic compounds.
-Because of its high alcohol, it can also be used as an alcohol reaction reagent in organic synthesis.
-It can also be used for research on methods for encoding and analyzing drugs or molecules.
Method:
The preparation method of 2,2-difluoro-2-(4-(trifluoromethoxy)phenyl)ethanol can be carried out in the following steps:
1. 4-trifluoromethoxybenzaldehyde is reacted with 2,2-difluoroacetic anhydride in the presence of a base to obtain 4-trifluoromethoxybenzeneacetic acid (benzeneacetic acid).
2.4-trifluoromethoxyphenylacetic acid is reacted with alkaline esterification reagent to obtain the corresponding esterification product.
3. The target compound is then obtained by the steps of O-fluorination, amide conversion and deprotection reaction.
Safety Information:
-Since there is currently no special hazard report on 2,2-difluoro-2-(4-(trifluoromethoxy)phenyl)ethanol, correct operation and protective measures are still necessary.
-Avoid contact with skin, eyes and mucous membranes during handling and use. In the case of accidental contact, the affected area should be flushed with water immediately and medical help should be sought promptly.
-It should be operated in a well-ventilated place, avoid inhaling its vapor or mist, and avoid contact with open flames or high temperature sources.
-During storage and handling, the relevant regulations and guidelines for chemicals should be strictly followed to ensure safe use.
Last Update：2024-04-09 21:04:16