2,2-difluoropropanamide - Names and Identifiers
2,2-difluoropropanamide - Physico-chemical Properties
Molecular Formula | C10H5ClF3N
|
Molar Mass | 231.6 |
Density | 1.427±0.06 g/cm3(Predicted) |
Melting Point | 48°C |
Boling Point | 265.5±35.0 °C(Predicted) |
Flash Point | 82.3°C |
Vapor Presure | 0.174mmHg at 25°C |
pKa | 2.45±0.16(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.359 |
MDL | MFCD00153106 |
2,2-difluoropropanamide - Risk and Safety
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin.
R36 - Irritating to the eyes
R25 - Toxic if swallowed
|
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
|
UN IDs | UN 2811 6.1 / PGIII |
WGK Germany | 3 |
Hazard Class | IRRITANT |
2,2-difluoropropanamide - Introduction
4-chloro-6-(trifluoromethyl)quinoline is an organic compound with the chemical formula C10H5ClF3N. It is a yellow solid with a special smell at room temperature. The following is a brief description of its nature, use, preparation and safety information:
Nature:
-Appearance: Yellow solid
-Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol and chloroform
-Density: 1.49g/cm³
-melting point: 75-80 ℃
-Boiling point: 260°C
-Storage conditions: prevent contact with oxygen, strong oxidants and high temperatures
Use:
4-choro-6-(trifluoromethyl)quinoline has certain applications in the field of medicine:
-As an organic synthesis intermediate for the synthesis of other compounds
-as a raw material for pesticides
-In drug research, it can be used as one of the structural elements of antigen tumor drugs
Preparation Method:
The preparation method of 4-chloro-6-(trifluoromethyl)quinoline is relatively complicated, and quinoline derivatives are usually used for synthesis. A common synthesis method is to react 2,3,4,5-tetrachloroquinoline and trifluoroacetic acid methyl ester in the presence of ammonia water, followed by dehydration chlorination, and finally to obtain the target product.
Safety Information:
- 4-chloro-6-(trifluoromethyl)quinoline should wear appropriate personal protective equipment, such as latex gloves and goggles, to avoid skin and eye contact.
-When handling the substance, avoid inhaling its dust or gas. In order to avoid inhalation, it is necessary to operate in a well-ventilated place.
-If ingested or inhaled, seek medical advice immediately and take out the label or container of the substance.
-During storage and transportation, keep away from heat sources, fire sources and oxidants to prevent fires and explosions.
Last Update:2024-04-09 15:17:58