2,2-二氟-1-(4-苯氧基苯基)环丙烷-1-羧酸 - Names and Identifiers
2,2-二氟-1-(4-苯氧基苯基)环丙烷-1-羧酸 - Introduction
2,2-difluoro-1-(4-phenoxyphenyl)cyclopropane-1-carboxylic acid is an organic compound with the chemical formula C16H11F2O2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 2,2-difluoro-1-(4-phenoxyphenyl)cyclopropane-1-carboxylic acid is a white crystalline solid.
-Melting point: about 175-176 ° C.
-Solubility: The compound is soluble in some organic solvents, such as dichloromethane and ether.
Use:
-As an intermediate in Organic Synthesis: 2,2-difluoro-1-(4-phenoxyphenyl)cyclopropane-1-carboxylic acid is commonly used as an intermediate for the preparation of anticancer drugs and other biologically active substances.
Method:
The preparation method of 2,2-difluoro-1-(4-phenoxyphenyl)cyclopropane-1-carboxylic acid includes the following steps:
1. 2,2-difluoro -1-(4-phenoxyphenyl) cyclopropane reacts with trifluoromethanesulfonic acid in an organic solvent to generate the corresponding trifluoromethanesulfonic acid salt.
2. Reaction of triflate with sodium carbonate under alkaline conditions to give 2,2-difluoro -1-(4-phenoxyphenyl) cyclopropane.
3. Finally, the resulting 2,2-difluoro-1-(4-phenoxyphenyl) Cyclopropane is reacted with sodium Dihydrogen carbonate under basic conditions to form 2,2-difluoro-1-(4-phenoxyphenyl)cyclopropane-1-carboxylic acid.
Safety Information:
The safety information of 2,2-difluoro-1-(4-phenoxyphenyl)cyclopropane-1-carboxylic acid has not been fully evaluated. Please refer to relevant safety information before use. When using this compound, it is recommended to wear appropriate personal protective equipment (such as gloves, goggles and protective clothing) and operate in a well-ventilated area. Care should be taken to prevent contact with skin and inhalation of gases or dust during handling and storage. In the event of an accident, you should immediately seek help from a professional or medical institution.
Last Update：2024-04-09 21:00:56