2,3-Dichloro-5-hydroxypyridine

2,3-Dichloro-5-hydroxypyridine - Names and Identifiers

Name	2,3-Dichloro-5-hydroxypyridine
Synonyms	5,6-Dichloropyridin-3-ol 5,6-dichloro-3-pyridinol 3-Pyridinol,5,6-dichloro- 3-pyridinol, 5,6-dichloro- 3-Dichloro-5-hydroxypyridine 2,3-Dichloro-5-hydropyridine 2,3-Dichloro-5-hydroxypyridine 5,6-Dichloro-3-hydroxypyridine 2,3-DICHLORO-5-HYDROXYPYRIDINE
CAS	110860-92-9
InChI	InChI=1/C5H3Cl2NO/c6-4-1-3(9)2-8-5(4)7/h1-2,9H

2,3-Dichloro-5-hydroxypyridine - Physico-chemical Properties

Molecular Formula	C5H3Cl2NO
Molar Mass	163.99
Density	1.561±0.06 g/cm3(Predicted)
Melting Point	184.0 to 188.0 °C
Boling Point	365.5±37.0 °C(Predicted)
Flash Point	174.8°C
Vapor Presure	7.45E-06mmHg at 25°C
Appearance	powder to crystal
Color	White to Light yellow to Light orange
pKa	7.91±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.602

2,3-Dichloro-5-hydroxypyridine - Introduction

2,3-Dichloro-5-hydroxypyridine is an organic compound with the chemical formula C5H3Cl2NO. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 2,3-dichloro-5-hydroxypyridine is a colorless to pale yellow crystalline solid.
-Solubility: It is almost insoluble in water and has better solubility in organic solvents.
-Chemical characteristics: It is a chlorine-substituted pyridine derivative with acid-base properties and redox properties.

Use:
-Chemical synthesis: 2,3-dichloro-5-hydroxypyridine can be used as an intermediate in organic synthesis. It is often used in the synthesis of other compounds in organic synthesis, such as pesticides, pharmaceuticals and dyes.
-Bactericide: This compound has antibacterial properties, so it can be used as a bactericide and preservative.

Preparation Method:
The preparation of 2,3-dichloro-5-hydroxypyridine can be carried out by the following methods:
1. Chlorine atom is introduced into the amino group of 3-chloro -2-hydroxypyridine, and cuprous chloride (CuCl) or ferric chloride (FeCl3) is used as catalyst.
2. 2,3-dichloro-5-hydroxypyridine is reacted with an appropriate reagent, such as ortho-ketone, keto acid, acid chloride, etc.

Safety Information:
-2,3-dichloro-5-hydroxypyridine is a toxic substance, irritating and corrosive. In the use or contact should pay attention to protective measures.
-Avoid direct inhalation of its dust or vapor, and avoid contact with skin and eyes.
-Use personal protective equipment such as protective gloves, goggles and protective clothing during operation.
-During storage and handling, it should be isolated from other chemicals, and the packaging should be properly sealed to avoid contact with oxidants and combustibles.

Please note that the above information is only a general introduction to 2,3-dichloro-5-hydroxypyridine. For specific use and operation, please refer to the safety manual and technical information of relevant chemicals.

Last Update：2024-04-09 20:49:11