2,3-Dichloropyazine
2,3-dichloropyrazine
CAS: 4858-85-9
Molecular Formula: C4H2Cl2N2
2,3-Dichloropyazine - Names and Identifiers
| Name | 2,3-dichloropyrazine |
| Synonyms | Dichloropyrazine 3-Dichloropyrazine 2,3-Dichloropyazine 2,3-dichloropyrazine 2,3-DICHLOROPYRAZINE 2,3-Dichloro pyrazine 2,3-Dichloro-1,4-diazine 2,3- twochlorinepyrazine |
| CAS | 4858-85-9 |
| EINECS | 225-460-1 |
| InChI | InChI=1/C4H2Cl2N2/c5-3-4(6)8-2-1-7-3/h1-2H |
2,3-Dichloropyazine - Physico-chemical Properties
| Molecular Formula | C4H2Cl2N2 |
| Molar Mass | 148.98 |
| Density | 1.431 g/mL at 25 °C (lit.) |
| Melting Point | 22.5-24.5 °C |
| Boling Point | 105-107 °C (50 mmHg) |
| Flash Point | 102 °C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.745mmHg at 25°C |
| Appearance | Solid |
| Specific Gravity | 1.431 |
| Color | Off-White to Light Yellow Low-Melting |
| BRN | 112628 |
| pKa | -4.23±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.5645 |
| Use | Used as a pharmaceutical Intermediate |
2,3-Dichloropyazine - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Hazard Class | IRRITANT |
2,3-Dichloropyazine - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| Use | 2,3-dichloropyrazine is an effective synthesis of aloine (an effective cyclin-dependent kinase) Substrate. Used as a pharmaceutical intermediate |
| production method | 1. the feed ratio (mass) of the synthesis process using 2,3-dihydroxypyrazine as raw material is 2,3-dicarboxylpyrazine: phosphorus oxychloride: catalyst (pyridine): ice water: ammonia water = 1:(5~5.5):(0.04~0.05):10.0: appropriate amount is put into the glass-lined chlorination kettle 2, 3-dihydroxypyrazine, phosphorus oxychloride and catalytic amount of pyridine are heated under stirring to reflux and reflux for 1.5~2h, and then part of phosphorus oxychloride is recovered by vacuum distillation. Then cool down, slowly add the material liquid to the neutralization kettle added with crushed ice in advance, and drop ammonia water from the processing industry at the same time to control ph ≈ 7 or so. After addition, chloroform is used to extract 2-3 times, then the extraction phase is combined, anhydrous sodium sulfate is added to dry, and filtered. The filtrate is distilled under reduced pressure, chloroform is recovered first, and finally a fraction of 125~130 ℃ at 4kpa, I .e. 2, 3-dichloropyrazine, is received. |
Last Update：2024-04-09 20:52:54
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