2,3-Indolinedione

2,3-Indolinedione - Names and Identifiers

Name	Isatin
Synonyms	Isatin Indole-2,3-dione 2,3-Indolinedione IRSOGLADINEMALEATE 1H-indole-2,3-dione Isatin, reagent grade ISATIN, TECHNICAL GRADE Isatin, synthesis grade ISATIN, PHARMACEUTICAL GRADE 2,3-DiketoindolineIndole-2,3-dione2,3-Indolinedione
CAS	91-56-5
EINECS	202-077-8
InChI	InChI:1S/C8H5NO2/c10-7-5-3-1-2-4-6(5)9-8(7)11/h1-4H,(H,9,10,11)
InChIKey	JXDYKVIHCLTXOP-UHFFFAOYSA-N

2,3-Indolinedione - Physico-chemical Properties

Molecular Formula	C8H5NO2
Molar Mass	147.13
Density	1.3067 (rough estimate)
Melting Point	193-195 °C (dec.) (lit.)
Boling Point	267.22°C (rough estimate)
Flash Point	220 °C
Water Solubility	Soluble in water (1.9 g/L at 20°C).
Solubility	Soluble in hot ethanol, slightly soluble in ether, soluble in hot water, benzene, acetone, soluble in alkali metal hydroxide oxide.
Vapor Presure	0Pa at 25℃
Appearance	Orange red single residual prism crystal
Color	Orange
Merck	14,5104
BRN	383659
pKa	10.34±0.20(Predicted)
PH	7 (1.9g/l, H2O, 20℃)
Storage Condition	Store below +30°C.
Stability	Stable. Incompatible with strong acids.
Refractive Index	1.4700 (estimate)
MDL	MFCD00005718
Physical and Chemical Properties	Appearance: yellow-red crystal Melting Point: 201-204 ℃
Use	For the preparation of vat dyes and drugs; Used as reagents for the determination of ketone and thiophene

2,3-Indolinedione - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes.
UN IDs	2811
WGK Germany	1
RTECS	NL7873000
TSCA	Yes
HS Code	29337900
Hazard Class	6.1(b)
Packing Group	III

2,3-Indolinedione - Reference

Reference

1. Zhang Yiming, Wan Hui Hua, Su Yong, Lu Meng, Yang Wei, Zhi Junwen. Effects of frostbite bluish on the contents of four indolyl derivatives in broad-sense postrinus plants [J]. Journal of Northwest Botany, 2020,40(11):1951-1958.
2. [IF = 4.162] Jiuling Deng et al."A Network Pharmacology-Based Investigation to the Pharmacodynamic Material Basis and Mechanisms of the Anti-coronary and Anti-Viral Effect of Isatis indigotica." Drug Des Dev Ther. 2021; 15: 3193-3206

2,3-Indolinedione - Introduction

It tastes bitter. Can sublimate. Easily soluble in boiling ethanol, the boiling water soluble in ether is reddish brown, soluble in alkali hydroxide is purple, and turns yellow after being placed. Solubility in water: 1.9g/l.

Last Update：2022-10-16 17:30:04

2,3-Indolinedione - Reference Information

. The chemical name is indole -2, 3-dione, which is orange-red monoclinic prism crystal at room temperature. Bitter taste. Molecular weight 147.13. Melting point 203.5 °c (partial sublimation). Soluble in hot water, hot ethanol, benzene, acetone, slightly soluble in ether. It is soluble in boiling alcohol, red-brown in ether and boiling water, purple in caustic solution and yellow in color. Its alcoholic solution has an extremely unpleasant odor. Weak alkaline, can be formed with perchloric acid salt. Isatin is mainly used as a dye and pharmaceutical intermediates, can produce drug sincofen, dye disperse Yellow E-3G. It can also be used as a chemical reagent, an analytical reagent, for analyzing and determining cuprous ions, mercaptans, thiols, thiophenes, urinary Cyanogen, etc. The isatin was prepared by condensation of aniline with trichloroacetaldehyde oxime, followed by cyclization and hydrolysis.

Decomposition	194 ºC
LogP	0.45
NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
isatin
purpose	This product is used as an intermediate for dyes and medicines, and is used in the production of drug sincofen, dye disperse Yellow E-3G; in chemical analysis, it is a reagent for measuring cuprous ion, thiol, thiophene, and urinary Cyanogen. used in the preparation of vat dyes and drugs, etc. used as a reagent for the determination of ketone and thiophene isatin as a reference material, used in the preparation of indigo and magulene; reagents for preparing naphthyridine derivatives, spirocyclic oxindole derivatives, and P-glycoprotein expression in multi-drug resistant cells; thiazol-4-one is fused to indole 2-one via a Spiro ring and acts as a potent and selective inhibitor of protein tyrosine phosphatase B of Mycobacterium tuberculosis, triazole-isatine complexes as potent antibacterial and antifungal agents, bioactive related structures such as Spiro (indole-thiazol-4-one); it is used for the tandem reaction with heterocyclic ketene aldolic amine and knoeventagel concentration reaction; Isatin uses the direct sp2/sp3C-H bond activation reaction, after Pd(II) catalyzed C- H addition reaction, formation of 3-substituted -3-hydroxy 2-hydroxyindole Check the precipitant for the ketone and silver. Spectrophotometric determination of thiophene, thiol, thiophene, urinary blue and proline reagent.
production method	first, oxime Acetanilide is prepared by condensation of aniline with trichloro acetaldehyde oxime, and then isatin red is prepared by hydrolysis through cyclization.
autoignition temperature	220°C

Last Update：2024-04-09 20:49:11

Nantong Reform Petro-Chemical CO., LTD.

Multiple SpecificationsSpot supply

Product Name: Isatin Request for quotation
CAS: 91-56-5
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865

Send QQ message

Jiangsu Pules Biotechnology Co.,Ltd.

Multiple Specifications

Product Name: Isatin Request for quotation
CAS: 91-56-5
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756

Hubei Longxin Chemical Industry Co., Ltd

Spot supply

Product Name: Isatin Request for quotation
CAS: 91-56-5
Tel: 15335994747
Email: 3521670276@qq.com
Mobile: 15335994747
QQ: 3521670276

Wechat: A2020071098

Hefei TNJ Chemical Industry Co.,Ltd.

Product Name: Isatin Request for quotation
CAS: 91-56-5
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840

Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog

Wuhan Xingzhongcheng Chemical limited company

Spot supply

Product Name: Isatin Request for quotation
CAS: 91-56-5
Tel: 86+027-83389957
Email: 1024042217@qq.com
Mobile: 86+18627766980
QQ: 1024042217

Wechat: 18627766980

Shanghai Yuanye Bio-Technology Co., Ltd.

Multiple SpecificationsSpot supply

Product Name: Isatin Visit Supplier Webpage Request for quotation
CAS: 91-56-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

江苏尚扬化工新材料有限公司

2,3-Indolinedione

Isatin

CAS: 91-56-5

Molecular Formula: C8H5NO2

2,3-Indolinedione - Names and Identifiers

2,3-Indolinedione - Physico-chemical Properties

2,3-Indolinedione - Risk and Safety

2,3-Indolinedione - Reference

2,3-Indolinedione - Introduction

2,3-Indolinedione - Reference Information

Supplier List

2,3-Indolinedione Request for Quotation

Isatin

CAS: 91-56-5

Molecular Formula: C8H5NO2

2,3-Indolinedione - Names and Identifiers

2,3-Indolinedione - Physico-chemical Properties

2,3-Indolinedione - Risk and Safety

2,3-Indolinedione - Reference

2,3-Indolinedione - Introduction

2,3-Indolinedione - Reference Information

Supplier List

2,3-Indolinedione