2,3-dichloro-5-fluoropyridine

2,3-dichloro-5-fluoropyridine - Names and Identifiers

Name	2,3-dichloro-5-fluoropyridine
Synonyms	2,3-dichloro-5-fluoropyridine 2,3-Dichloro-5-fluoropyridine Pyridine, 2,3-dichloro-5-fluoro- pyridine, 2,3-dichloro-5-fluoro-
CAS	185985-40-4
EINECS	251-156-6
InChI	InChI=1/C5H2Cl2FN/c6-4-1-3(8)2-9-5(4)7/h1-2H

2,3-dichloro-5-fluoropyridine - Physico-chemical Properties

Molecular Formula	C5H2Cl2FN
Molar Mass	165.98
Density	1.498±0.06 g/cm3(Predicted)
Boling Point	174.0±35.0 °C(Predicted)
Flash Point	59.1°C
Water Solubility	Slightly soluble in chloroform, methanol and water.
Vapor Presure	1.65mmHg at 25°C
Appearance	Solid
pKa	-2.97±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.528

2,3-dichloro-5-fluoropyridine - Introduction

2,3-dichloro-5-fluoropyridine, also known as 2,3-dichloro-5-fluoropyridine, is an organic compound. The following is a description of its nature, use, formulation and safety information:

Nature:
-chemical formula: C5H2Cl2FN
-Molecular weight: 153.98g/mol
-Appearance: Colorless to light yellow crystal or liquid
-Melting point:-2 ° C
-Boiling point: 80-82 ° C
-Solubility: Soluble in organic solvents, insoluble in water

Use:
2,3-dichloro-5-fluoropyridine has certain application value in organic synthesis and pharmaceutical chemistry, and is usually used as an intermediate or raw material.

Method:
The preparation of 2,3-dichloro-5-fluoropyridine can usually be carried out by the following steps:
1. 2,3-dibromo-5-fluoropyridine is reacted with anhydrous ammonium chloride to obtain the intermediate of 2,3-dichloro-5-fluoropyridine.
2. In the presence of alkali, and then react with sodium bisulfite to obtain the target product.

Safety Information:
- 2,3-dichloro-5-fluoropyridine requires attention to protective measures during use, including wearing protective gloves, goggles and masks.
-Avoid breathing its vapors or contact with skin, eyes and clothing.
-Maintain good ventilation during operation.
-If taken by mistake or inhaled, seek medical assistance immediately.
-Detailed safety operation procedures should be formulated and followed according to specific conditions and relevant safety regulations.

Please note that 2,3-dichloro-5-fluoropyridine is a chemical and must follow safe operating procedures and consult a professional for guidance.

Last Update：2024-04-09 19:05:47