2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on
Dihydromyricetin
CAS: 27200-12-0
Molecular Formula: C15H12O8
2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on - Names and Identifiers
| Name | Dihydromyricetin |
| Synonyms | Ampelopsin Dihydromyricetin (+)-Dihydromyricetin Two hydrogenMyricetin DihydroMyricetin, froM Myrica rubra 3,3',4',5,5',7-hexahydroxy-flavanon Dihydromyricetin(+)-Dihydromyricetin 3,3',4',5,5',7-hexahydroxy-2,3-dihydroflavanonol (2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one Ampelopsin(2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one 2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydro-4H-chromen-4-one |
| CAS | 27200-12-0 |
| EINECS | 200-001-8 |
| InChI | InChI=1/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1 |
| InChIKey | KJXSIXMJHKAJOD-LSDHHAIUSA-N |
2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on - Physico-chemical Properties
| Molecular Formula | C15H12O8 |
| Molar Mass | 320.25 |
| Density | 1.808±0.06 g/cm3(Predicted) |
| Melting Point | 239-241 °C |
| Boling Point | 780.7±60.0 °C(Predicted) |
| Flash Point | 296.7°C |
| Solubility | Soluble in hot water, hot ethanol and acetone, soluble in ethanol, methanol, very slightly soluble in ethyl acetate, insoluble in chloroform, petroleum ether. |
| Vapor Presure | 1.16E-25mmHg at 25°C |
| Appearance | White or white-like powder |
| Color | white to beige |
| pKa | 7.38±0.60(Predicted) |
| Storage Condition | -20°C |
| Stability | Hygroscopic |
| Refractive Index | 1.798 |
| MDL | MFCD00189451 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the stems and leaves of Ampelopsis grossedentata. |
2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29329990 |
2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on - Introduction
Ampelopsis grossedentata extract:
Fujimoto tea tree is a rare and typical tea tree. It is known as dragon boat tea and longxu tea. It grows in hillside shrubs or valley woodlands at an altitude of 1300-1950 meters. It is known as the legendary health tea. Studies have shown that Ampelopsis grossedentata has anti-inflammatory and anti-cough effects, and also has a strong inhibitory effect on common bacteria in food.
Introduction of dihydromyricetin
Dihydromyricetin (DHM) is a natural extract of Ampelopsis grossedentata. For centuries, DHM has been used in Chinese medicine to treat hangovers and liquors.
Staphylococci, dihydromyricetin and other flavonoids in Ampelopsis grossedentata are the main active ingredients, and its MIC and MBC are basically the same as those of berberine, and its free radical scavenging activity is between 73.3 and 91.5. It can also reduce oxidative damage in the body, delay aging, reduce liver deformation and tissue necrosis.
How does dihydromyricetin powder work?
Apart from dihydromyricetin powder, no other product is more effective in reducing hangover symptoms. It has been extensively studied in mice and interacts with alcohol in a very unique way.
First, dihydromyricetin powder is actually able to suppress the effects of alcohol on the brain. It does this by binding to GABA receptors. GABA is a neurotransmitter affected by alcohol. After alcohol enters your bloodstream and reaches your brain, it binds to GABA receptors and enhances the effects you get from the GABA neurotransmitter. This can cause your heart rate to slow down, feel relaxed, and ultimately lead to drunkenness. Dihydromyricetin powder also binds to GABA receptors and softens the effects of alcohol on them. This can reduce acute alcohol withdrawal the next day, thereby reducing hangover symptoms.
Second, dihydromyricetin powder can enhance the liver's ability to metabolize alcohol and acetaldehyde, a toxic byproduct of alcohol. When alcohol is metabolized in the liver, it is converted to acetaldehyde. Acetaldehyde is much more toxic than alcohol and can cause extreme nausea, headaches and sensitivity to light. Dihydromyricetin powder can help your body remove acetaldehyde faster, thereby reducing the symptoms of a hangover the next day.
Last Update：2023-08-16 23:22:23
2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on - Reference Information
| rattan tea extract | dihydromyricetin (dihydromyricetin,DMY) is a wild woody vine (rattan tea) extract of the genus Vitis, also known as dihydrobayberry bark, dihydromyricetin, snake grape, etc. rattan tea is also known as "berry tea", Shentang berry, Maoyan enzyme tea, longevity vine, etc. The folk have the habit of drinking berry tea since ancient times, which can be traced back to the ancient Shennong tasting Baicao period, which has a history of more than 6000 years. The earliest "Book of Songs Collection" in China is called ancient tea gouteng. The taste is bitter first and then sweet, and the return is strong. Dihydromyricetin is an extract of the grape plant Ampelopsis. It is the main active ingredient in Ampelopsis. Flavonoids, such substances have a variety of unique effects such as scavenging free radicals, anti-oxidation, anti-thrombosis, anti-tumor, anti-inflammatory, etc.; and dihydromyricetin is a relatively special kind of flavonoid compound, it has special effects in relieving alcohol poisoning, preventing alcoholic liver and fatty liver, inhibiting liver cell deterioration, reducing the incidence of liver cancer, anti-hypertension, inhibiting platelet aggregation in vitro and thrombosis in vivo, reducing blood lipid and blood sugar levels, improving SOD activity and protecting liver and liver. |
| Biological activity | Dihydromyricetin is an antioxidant and a competitive GABAA antagonist. Dihydromyricetin competitively inhibits benzodiazepine sites, induces autophagy and shows antiproliferative effects. |
| pharmacological action | myricetin is one of the main active ingredients of rattan tea. it has a variety of biological functions and has a variety of unique effects such as scavenging free radicals, anti-oxidation, anti-hypertension, anti-thrombosis, anti-tumor, anti-inflammatory, etc. Dihydromyricetin, as a special flavonoid compound, in addition to the general characteristics of flavonoids, also has the effects of relieving alcoholism, preventing alcoholic liver, fatty liver, inhibiting liver cell deterioration, and reducing the incidence of liver cancer. It is a good product to protect the liver and protect the liver, relieve alcohol and sober up. Antibacterial effect: Pharmacological experiments show that dihydromyricetin has antibacterial effects on Bacillus subtilis, Staphylococcus aureus, Salmonella, Escherichia coli, Aerogenes, Saccharomyces cerevisiae, Penicillium, Aspergillus niger, Aspergillus flavus, Mucor and Rhizopus, especially on Gram-positive, Gram-negative cocci or bacilli. Regulating effect on blood sugar and blood lipids: The experiment of gavage in mice showed that dihydromyricetin can significantly inhibit the increase in blood sugar in mice induced by alloxan, epinephrine, and streptozotocin, and increase serum insulin. Levels, lymphocyte infiltration in pancreatic tissue is significantly reduced, inflammation is significantly reduced, and the number of islets is significantly increased. Dihydromyricetin can reduce the content of serum triglyceride (TG) in streptozotocin-induced hyperglycemia rats, but has no obvious effect on the content of serum total cholesterol (TC) and high density lipoprotein cholesterol (HDL2C). Liver protection: Dihydromyricetin has a significant protective effect on toxic damage of carbon tetrachloride in rat hepatocytes cultured in vitro, and liver injury induced by D2 galactosamine and lipopolysaccharide in mice. Dihydromyricetin can protect the liver, accelerate the rapid decomposition of the ethanol metabolite acetaldehyde, become a non-toxic substance, and reduce its damage to liver cells. In addition, dihydromyricetin can improve the increase of serum lactate dehydrogenase activity caused by liver cell damage, inhibit the formation of hepatic M cell collagen fibers, thereby protecting the liver and greatly reducing the damage of ethanol to the liver. The normal state of the liver is quickly restored. Microherb tests have proved that dihydromyricetin can protect the liver, accelerate the rapid decomposition of the ethanol metabolite acetaldehyde, turn into a non-toxic substance, and reduce the damage to liver cells. Dihydromyricetin takes effect quickly and has a long-lasting effect. It is a good product for protecting the liver and relieving alcohol and sobering up. Antioxidant effect: Dihydromyricetin with 98% purity can obviously inhibit the production of malondialdehyde (MDA) in homogenate of rat myocardium, liver and brain tissue, and inhibit the production of MDA with the increase of dihydromyricetin concentration. The scavenging rate of diphenyltrinitrophenylhydrazine (DPPH) radical in the test system with 99% content of dihydromyricetin. Dihydromyricetin can obviously inhibit the formation of MDA in oil, and its antioxidant effect is enhanced with the increase of dihydromyricetin purity (60% ~ 90%). It has strong antioxidant effect on animal oil and vegetable oil. Anti-tumor effect: In recent years, anti-tumor pharmacodynamics studies have found that one of its active ingredients, the small molecule compound of snake grape-grape, has a relatively strong anti-cancer effect. In vitro anti-tumor effect studies have found that the compound can improve the effect of tumor treatment and improve the patient's life symptoms by inhibiting tumor vascular growth and regulating and enhancing cellular immune function. It has been used in tumor model tests such as leukemia and nasopharyngeal carcinoma. It has shown obvious anti-tumor effect. |
| market prospect | snake grape, also known as rattan tea, is a traditional folk medicine and has been widely used to treat infectious diseases such as skin diseases, boils, osteomyelitis, acute lymphadenitis, etc. Dihydromyricetin is widely used in Chinese patent medicine preparations for the treatment of respiratory tract infections and alcoholism, such as tablets, capsules, and granules. In recent years, anti-tumor pharmacodynamics studies have found that one of its active ingredients, the small molecule compound of snake grape, has a strong anti-cancer effect. The research of dihydromyricetin has obtained the invention patent authorization in the application field of the preparation of anti-leukemia and nasopharyngeal carcinoma drugs. It has been prepared to enter the clinical trial stage as a new drug. The development of a new traditional Chinese medicine snake grape hormone injection is expected to provide a new therapeutic drug for the majority of patients with leukemia and nasopharyngeal carcinoma. The Microherb completed the extraction and purification technology of rattan tea extract (total flavonoids of snake grape) and dihydromyricetin, and completed related toxicological experiments and efficacy studies, and used dihydromyricetin as the efficacy addition ingredient Developed health foods such as instant tea, total flavonoids tablets of snake grape, and dihydromyricetin detoxifying and protecting the liver. |
| use | a flavonol with antioxidant and anticancer activities, with anti-alcoholic effects. This product is an extract of vine tea from the genus Vitis. The main active ingredient in vine tea is flavonoids, which have many peculiar effects such as scavenging free radicals, anti-oxidation, anti-thrombosis, anti-tumor, anti-inflammatory, etc.; And dihydromyricetin is a relatively special kind of flavonoid compound, in addition to the general characteristics of flavonoids, it also has the effects of relieving alcohol poisoning, preventing alcoholic liver and fatty liver, inhibiting liver cell deterioration, and reducing the incidence of liver cancer. |
Last Update：2024-04-09 21:32:05
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