2,3-dimethyl-5-oxo-1-phenyl-3-pyrazoline-4-carboxaldehyde
4-antipyrinecarboxaldehyde
CAS: 950-81-2
Molecular Formula: C12H12N2O2
2,3-dimethyl-5-oxo-1-phenyl-3-pyrazoline-4-carboxaldehyde - Names and Identifiers
2,3-dimethyl-5-oxo-1-phenyl-3-pyrazoline-4-carboxaldehyde - Physico-chemical Properties
| Molecular Formula | C12H12N2O2 |
| Molar Mass | 216.24 |
| Density | 1.292±0.06 g/cm3(Predicted) |
| Melting Point | 162-165 °C (lit.) |
| Boling Point | 334.8±52.0 °C(Predicted) |
| Flash Point | 145.4°C |
| Vapor Presure | 0.000125mmHg at 25°C |
| pKa | -1.39±0.60(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.651 |
2,3-dimethyl-5-oxo-1-phenyl-3-pyrazoline-4-carboxaldehyde - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| Hazard Note | Irritant |
2,3-dimethyl-5-oxo-1-phenyl-3-pyrazoline-4-carboxaldehyde - Reference Information
| Overview | Antipyrine is also known as phenones. Colorless or white crystalline powder, odorless, slightly bitter taste. Melting point 110-113 °c. Soluble in water, ethanol, chloroform, slightly soluble in ether. From phenylhydrazine and butanone amide after cyclization, and then dimethyl sulfate methylation reaction. For antipyretic drugs, the role of rapid, long duration, with a weak analgesic, antispasmodic effect. Antipyrine (PZ), a widely used anti-inflammatory and analgesic drug, was detected by researchers in Berlin groundwater and drinking water in Germany, along with its metabolites. |
| Use | studies have shown that Antipyrine is toxic to the lung and mucosa, and long-term exposure will lead to target organ damage, 4-antipyrine formaldehyde is a derivative of antipyrine, which can be used as a pharmaceutical synthesis intermediate. |
| preparation | 4-antipyrine formaldehyde preparation is as follows: (1) Antipyrine is added to the preparation tank, add the amount of sulfuric acid and water, with the content of 34-36% of the acidic solution, and then with the sodium nitrite solution in the nitrosation barrel for nitrosation reaction, the reaction solution into the reducing tank, add reducing agent for reduction reaction, then, the reducing solution was transferred to the hydrolysis tank, and after hydrolysis with sulfuric acid, ammonia gas was introduced for neutralization to prepare 4-aminoantipyrine oil; (2) the 4-aminoantipyrine oil is added to an acylation tank to undergo an acylation reaction with methyl formate or formic acid, and then the temperature-reduced crystallization is centrifuged to obtain 4-antipyrine formaldehyde crystals. |
Last Update：2024-04-09 02:00:12
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CAS: 950-81-2
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