2,3-二氢-2,2-二甲基-7-羟基苯并呋喃
2,3-dihydro-2,2-dimethyl-7-benzofuranol
CAS: 1563-38-8
Molecular Formula: C10H12O2
2,3-二氢-2,2-二甲基-7-羟基苯并呋喃 - Names and Identifiers
2,3-二氢-2,2-二甲基-7-羟基苯并呋喃 - Physico-chemical Properties
| Molecular Formula | C10H12O2 |
| Molar Mass | 164.2 |
| Density | 1.101 g/mL at 25 °C (lit.) |
| Boling Point | 95°C 1mm |
| Flash Point | >230°F |
| Solubility | Chloroform (Slightly), Methanol (Sparingly) |
| Vapor Presure | 0.839mmHg at 25°C |
| Appearance | White crystal |
| Specific Gravity | 1.101 |
| Color | Colourless |
| pKa | 10.10±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | n20/D 1.541(lit.) |
| MDL | MFCD00075382 |
| Physical and Chemical Properties | Pure, colorless liquid, B. p. 78 ℃/40.0, 92 ℃/267Pa, relative density 1.101, viscosity 170.12 × 10-3Pa · s at 20 ℃, specific heat capacity 1.40J/(g · ℃), heat of vaporization is 108.7J/g, heat of combustion is 5164.6kJ/mol, soluble in dichloromethane, toluene, alcohol, ether and other organic solvents, insoluble in water. |
| Use | Is the main intermediate of the production of pesticide carbofuran |
2,3-二氢-2,2-二甲基-7-羟基苯并呋喃 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 3082 9 / PGIII |
| WGK Germany | 3 |
| RTECS | DF7708985 |
2,3-二氢-2,2-二甲基-7-羟基苯并呋喃 - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Use | 2, 3-dihydro-2, 2-dimethyl-7-hydroxybenzofuran is abbreviated as 7-hydroxyfuran, Furan phenol is an important intermediate for the synthesis of carbofuran (carbofuran). is the main intermediate for the production of pesticide carbofuran |
| Production method | In foreign countries, in addition to FMC in the United States, Carbofuran's intermediate furan production plant, there are Norwegian Pauligg Company and Japan Mitsubishi Company. Hungary has a small amount of production, but the quality is not ideal. The synthesis routes of furan phenol reported in the literature are as follows: o-nitrophenol method, guaiacol method, o-chlorophenol method, hydroxyacetophenone method, o-isopropyl phenol method, cyclohexanone method, benzofuran method and catechol method. Among them, the catechol method has the least reaction steps and the yield can reach 64%. The raw material catechol is a product with a large output in the world, which is relatively cheap and easy to obtain. Therefore, this method is an ideal method for preparing furan phenol. Using catechol as raw material, there are three methods to synthesize furan phenol, among which the reaction method of catechol and methyl allyl chloride has few steps and the total yield is more than 64%, which is currently a more suitable synthesis method. FMC Company of the United States successfully researched and developed this synthesis method and established an industrial production unit. Synthesis of 2-Methylallyl Chloride (MAC) Isobutene and liquid chlorine are measured separately after vaporization, and then passed into the reactor according to the appropriate ratio. The reaction is strongly exothermic, and the reaction contact time needs to be strictly controlled, and The reaction is evenly mixed in an instant. After the reaction, the material enters the reaction evaporator, removes the reaction heat, and then enters the absorption condenser to absorb hydrogen chloride into hydrochloric acid, and then after cooling and oleic acid separation, hydrochloric acid can be sold as a by-product, and the organic layer is fractionated to obtain MAC products, The content can reach 95% ~ 98%. Synthesis of o-(2-methylallyloxy) phenol (mono-ether for short) Catechol, anhydrous sodium carbonate and solvent are added to the reaction kettle according to a reasonable ratio, 2-methyl allyl chloride (MAC) is added dropwise under stirring, the reaction temperature and time 19 are controlled, the water generated in the reaction is separated, then the material is cooled, the salt residue is filtered to be removed, and then the product mono-ether is obtained under reduced pressure. Synthesis of 2, 3-dihydro-2, 2-dimethyl-7-hydroxybenzofuran (referred to as furan phenol). Monoether, catalyst and xylene are added to the closed-loop kettle according to the appropriate ratio, stirred and heated to the reaction temperature for closed-loop reaction, and then decompressed and dissolving to evaporate xylene for recycling. After the dissolving, the material is subjected to vacuum distillation, the content of the obtained furan phenol is ≥ 95%, and the distillation residue is sent to three wastes for treatment. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 15:16:48
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View History
2,3-二氢-2,2-二甲基-7-羟基苯并呋喃
TBC-11249
(1,10-菲啰啉)双(三苯基磷)硝酸铜 二氯甲烷络合物
Dimethylcyclohexylethoxy isobutylpropanoate
2-Hydroxyethylthiomethylbenzene
3-(N,N-Dimethylaminomethyl)-5-methyl-2-hexanone oxalate
8-甲氧基-2-(三氟甲基)喹啉-5-羧酸
(6-ETHYL-4-OXO-3-PHENYL-3,4-DIHYDRO-THIENO[2,3-D]PYRIMIDIN-2-YLSULFANYL)-ACETIC ACID
(S)-1-Boc-2-isopropyl-piperazine (HCL)
4-AMINO-7-CHLORO-2-METHYLQUINOLINE
TBC-11249
(1,10-菲啰啉)双(三苯基磷)硝酸铜 二氯甲烷络合物
Dimethylcyclohexylethoxy isobutylpropanoate
2-Hydroxyethylthiomethylbenzene
3-(N,N-Dimethylaminomethyl)-5-methyl-2-hexanone oxalate
8-甲氧基-2-(三氟甲基)喹啉-5-羧酸
(6-ETHYL-4-OXO-3-PHENYL-3,4-DIHYDRO-THIENO[2,3-D]PYRIMIDIN-2-YLSULFANYL)-ACETIC ACID
(S)-1-Boc-2-isopropyl-piperazine (HCL)
4-AMINO-7-CHLORO-2-METHYLQUINOLINE