2,4,6-Trichloro-5-methylpyrimidine
Pyrimidine, 2,4,6-trichloro-5-methyl-
CAS: 1780-36-5
Molecular Formula: C5H3Cl3N2
2,4,6-Trichloro-5-methylpyrimidine - Names and Identifiers
| Name | Pyrimidine, 2,4,6-trichloro-5-methyl- |
| Synonyms | 2,4,6-Trichoro-5-MethylpyriMidine 2,4,6-Trichloro-5-MethylpyriMidine 2,4,6-TRICHLORO-5-METHYLPYRIMIDINE 2,4,6-Trichloro-5-methylpyrimidine 5-Methyl-2,4,6-trichloropyrimidine Pyrimidine, 2,4,6-trichloro-5-methyl- |
| CAS | 1780-36-5 |
| InChI | InChI=1/C6H13NO/c7-5-2-1-3-6(8)4-5/h5-6,8H,1-4,7H2 |
2,4,6-Trichloro-5-methylpyrimidine - Physico-chemical Properties
| Molecular Formula | C5H3Cl3N2 |
| Molar Mass | 197.45 |
| Density | 1.542±0.06 g/cm3(Predicted) |
| Melting Point | 65-69 °C |
| Boling Point | 132-136 °C(Press: 23-25 Torr) |
| Flash Point | 75.4°C |
| Vapor Presure | 0.0773mmHg at 25°C |
| pKa | -6.75±0.39(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.502 |
2,4,6-Trichloro-5-methylpyrimidine - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R22 - Harmful if swallowed R34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3261 |
| WGK Germany | 3 |
| HS Code | 29335990 |
| Hazard Class | 8 |
| Packing Group | Ⅱ |
2,4,6-Trichloro-5-methylpyrimidine - Introduction
Pyrimidine, 2,4,6-trichloro-5-methyl-is an organic compound with the chemical formula C5H3Cl3N2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: Pyrimidine, 2,4, 6-tricholoro-5-methyl-is a colorless crystalline solid.
-Melting point: About 120-121 degrees Celsius.
-Solubility: It can be dissolved in water, and soluble in organic solvents such as methanol and ethanol.
-Chemical properties: It is a weakly alkaline substance and is easy to hydrolyze.
Use:
-Pesticide: Pyrimidine, 2,4, 6-tricloro-5-methyl-is an effective weed control agent, commonly used in the preparation of glyphosate.
-Laboratory research: It can be used as an intermediate in organic synthesis and is widely used in organic synthesis reactions.
-Pharmaceutical field: Some studies have shown that it may have anti-tumor activity and antiviral activity, but further research and verification are still needed.
Method:
The preparation method of Pyrimidine, 2,4, 6-tricloro-5-methyl-usually involves the following steps:
1. Methylation: The methyl bromide reacts with pyrimidine under alkaline conditions to produce 5-methyl pyrimidine.
2. Chlorination: reacting 5-methyl Pyrimidine with chlorine in the presence of chlorinating reagent to generate Pyrimidine, 2,4, 6-trichlororo-5-methyl-.
Safety Information:
- Pyrimidine, 2,4, 6-tricloro-5-methyl-is a toxic substance, and direct contact and inhalation of its dust or vapor should be avoided.
-Wear appropriate personal protective equipment, such as gloves, goggles and protective clothing, during use or handling.
-It should be operated in a well-ventilated place and try to avoid it from entering the environment.
-In case of accidental contact or inhalation, rinse immediately with water and seek medical help as soon as possible.
-store should be sealed, away from fire and oxidant, and in a cool, dry place.
Nature:
-Appearance: Pyrimidine, 2,4, 6-tricholoro-5-methyl-is a colorless crystalline solid.
-Melting point: About 120-121 degrees Celsius.
-Solubility: It can be dissolved in water, and soluble in organic solvents such as methanol and ethanol.
-Chemical properties: It is a weakly alkaline substance and is easy to hydrolyze.
Use:
-Pesticide: Pyrimidine, 2,4, 6-tricloro-5-methyl-is an effective weed control agent, commonly used in the preparation of glyphosate.
-Laboratory research: It can be used as an intermediate in organic synthesis and is widely used in organic synthesis reactions.
-Pharmaceutical field: Some studies have shown that it may have anti-tumor activity and antiviral activity, but further research and verification are still needed.
Method:
The preparation method of Pyrimidine, 2,4, 6-tricloro-5-methyl-usually involves the following steps:
1. Methylation: The methyl bromide reacts with pyrimidine under alkaline conditions to produce 5-methyl pyrimidine.
2. Chlorination: reacting 5-methyl Pyrimidine with chlorine in the presence of chlorinating reagent to generate Pyrimidine, 2,4, 6-trichlororo-5-methyl-.
Safety Information:
- Pyrimidine, 2,4, 6-tricloro-5-methyl-is a toxic substance, and direct contact and inhalation of its dust or vapor should be avoided.
-Wear appropriate personal protective equipment, such as gloves, goggles and protective clothing, during use or handling.
-It should be operated in a well-ventilated place and try to avoid it from entering the environment.
-In case of accidental contact or inhalation, rinse immediately with water and seek medical help as soon as possible.
-store should be sealed, away from fire and oxidant, and in a cool, dry place.
Last Update：2024-04-09 15:17:54
