2,4-Diamino-6-(Hydroxymethyl)Pteridine

2,4-Diamino-6-(Hydroxymethyl)Pteridine - Names and Identifiers

Name	2,4-diamino-6-hydroxymethylpteridine
Synonyms	AKOS 213-118 2,4-DIAMINO-6-PTERIDINEMETHANOL 2,4-diaminopteridine-6-ylmethanol (2,4-DIAMINO-6-PTERIDINYL)METHANOL (2,4-Diamino-6-pteridinyl)methanol (2,4-DIAMINO-PTERIDIN-6-YL)-METHANOL 2,4-diamino-6-hydroxymethylpteridine 2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE 2,4-Diamino-6-(Hydroxymethyl)Pteridine 2,4-Diamino-6-(hydroxymethyl) pteridine 2,4-Diamino-6-hydroxymethylpteridine hydrochloride or HBR
CAS	945-24-4
EINECS	213-412-2
InChI	InChI=1/C7H8N6O/c8-5-4-6(13-7(9)12-5)10-1-3(2-14)11-4/h1,14H,2H2,(H4,8,9,10,12,13)

2,4-Diamino-6-(Hydroxymethyl)Pteridine - Physico-chemical Properties

Molecular Formula	C7H8N6O
Molar Mass	192.18
Density	1.673±0.06 g/cm3(Predicted)
Melting Point	333-334 °C (decomp)
Boling Point	560.2±60.0 °C(Predicted)
pKa	12.00±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,2-8°C

2,4-Diamino-6-(Hydroxymethyl)Pteridine - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed
WGK Germany	3

2,4-Diamino-6-(Hydroxymethyl)Pteridine - Reference Information

purpose

? 2,4 diamino 6 bromomethyl pteridine is a key intermediate for the synthesis of methotrexate, literature and patent reports of diketene as raw materials, after bromine addition, diazotization, and then with 2,4,5, preparation of 6 Four amino pyrimidine sulfate ring. The

preparation

a method for preparing 2,4 diamino 6 bromomethyl pteridine with 1,3 dihydroxyacetone and 2,4,5,6 Four amino pyrimidine hydrochloride in acidic molecular sieve catalyzed cyclization directly in one step to obtain high purity 2,4 diamino 6 hydroxymethyl pteridine. After the reaction is completed, the product can be obtained by direct filtration, and the operation process is simple and the cost is low. The technical scheme is the preparation of an improved 2,4 diamino 6 bromomethyl pteridine, the reaction takes 2,4,5,6 Four amino pyrimidine hydrochloride as raw material, acidic 4A molecular sieve as a catalyst, in the presence of oxygen and 1,3 dihydroxyacetone reaction to produce 2,4 diamino 6 hydroxymethyl pteridine, and then in the NBS and triphenylphosphine bromine under the action of product 2,4 diamino 6 bromomethyl pteridine.

Last Update：2024-04-09 15:16:53