2,4-Dichloro-5-methoxypyrimidine
2,4-Dichloro-5-Methoxy-Pyrimidine
CAS: 19646-07-2
Molecular Formula: C5H4Cl2N2O
2,4-Dichloro-5-methoxypyrimidine - Names and Identifiers
| Name | 2,4-Dichloro-5-Methoxy-Pyrimidine |
| Synonyms | 2,4-Dichloro-5-methoxpyrimidine 2,4-Dichloro-5-methoxypyrimidine 5-METHOXY-2,4-DICHLORO PYRIMIDINE 2,4-AICHLORO-5-METHOXY PYRIMIDINE 2,4-Dichloro-5-Methoxy-Pyrimidine 2,4- twochloro -5-MethoxypyriMidine 5-Methoxy-2,4-Dichloropyrimidine pyrimidine 2,4-Dichloro-5-methoxy-1,3-diazine, 2,4-Dichloropyrimidin-5-yl methyl ether |
| CAS | 19646-07-2 |
| EINECS | 628-558-6 |
| InChI | InChI=1/C5H4Cl2N2O/c1-10-3-2-8-5(7)9-4(3)6/h2H,1H3 |
| InChIKey | ZTHHRSBDBPCCMZ-UHFFFAOYSA-N |
2,4-Dichloro-5-methoxypyrimidine - Physico-chemical Properties
| Molecular Formula | C5H4Cl2N2O |
| Molar Mass | 179 |
| Density | 1.446±0.06 g/cm3(Predicted) |
| Melting Point | 66-70 °C |
| Boling Point | 259.9±20.0 °C(Predicted) |
| Flash Point | 111°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 0.0204mmHg at 25°C |
| Appearance | Crystalline powder |
| Color | White to Almost white |
| pKa | -2.67±0.29(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.541 |
| MDL | MFCD02685670 |
2,4-Dichloro-5-methoxypyrimidine - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| WGK Germany | 3 |
| HS Code | 29335990 |
| Hazard Note | Harmful |
| Hazard Class | IRRITANT, CORROSIVE |
2,4-Dichloro-5-methoxypyrimidine - Reference Information
| introduction | 2, 4-dichloro-5-methoxypyrimidine is an organic synthesis intermediate of heterocyclic compounds, which has a white or light yellow appearance at room temperature and pressure Solid, has good solubility in strong polar solvents, but not good solubility in water. |
| Uses | 2,4-dichloro-5-methoxypyrimidine is used as an intermediate in the organic synthesis of heterocyclic compounds. Its uses include the use of chlorine atoms on the ring. Coupling or related functional group conversion reactions. Interestingly, the reactivity of the two chlorine atoms of this compound, the chlorine at position 4, is much higher than that of the chlorine atom at position 2. For example, the compound can react with ammonia to convert the chlorine atom at position 4 into an amine group; in addition, the chlorine atom at position 4 can also react with methanol to introduce a methoxy group at position 4. |
| Synthesis method | 2, 4-dichloro-5-methoxypyrimidine The synthesis method starts from 5-methoxyuracil and reacts with pyridine and phosphorus oxychloride at high temperature to obtain the target product of deoxychlorination. It is worth noting that this reaction requires high temperature and the pressure during the reaction will also change, therefore, the relevant literature should be fully consulted and the appropriate reaction vessel should be prepared before the reaction is carried out. |
Last Update：2024-04-10 22:29:15
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