2,4-Dichloro-6-methylaniline
2,4-Dichloro-6-methylaniline
CAS: 30273-00-8
Molecular Formula: C7H7Cl2N
2,4-Dichloro-6-methylaniline - Names and Identifiers
| Name | 2,4-Dichloro-6-methylaniline |
| Synonyms | TIMTEC-BB SBB003781 4,6-Dichloro-o-toluidine 2-amino-3,5-dichlorotoluene 2,4-DICHLORO-6-METHYLANILINE 2,4-Dichloro-6-methylaniline Benzenamine, 2,4-dichloro-6-methyl- 2-Amino-3,5-dichlorotoluene, 4,6-Dichloro-o-toluidine |
| CAS | 30273-00-8 |
| EINECS | 625-812-8 |
| InChI | InChI=1/C7H7Cl2N/c1-4-2-5(8)3-6(9)7(4)10/h2-3H,10H2,1H3 |
2,4-Dichloro-6-methylaniline - Physico-chemical Properties
| Molecular Formula | C7H7Cl2N |
| Molar Mass | 176.04 |
| Density | 1.334±0.06 g/cm3(Predicted) |
| Melting Point | 42-46 °C (lit.) |
| Boling Point | 82-84°C 0,1mm |
| Flash Point | >230°F |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.0101mmHg at 25°C |
| Appearance | Solid |
| Color | Pale Beige to Light Brown Low-Melting |
| BRN | 2208221 |
| pKa | 1.87±0.10(Predicted) |
| Storage Condition | -20°C Freezer, Under inert atmosphere |
| Refractive Index | 1.599 |
| MDL | MFCD00044074 |
2,4-Dichloro-6-methylaniline - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29214300 |
| Hazard Note | Irritant |
2,4-Dichloro-6-methylaniline - Introduction
2,4-dichloro-6-methylaniline (2,4-dichloro-6-methylaniline) is an organic compound. Its chemical formula is C7H8Cl2N and its molecular weight is 183.05g/mol. The following is a detailed description of the properties, uses, preparation and safety information of the substance:
Nature:
-Appearance: Colorless or yellow crystal
-Melting point: 69-71 ℃
-Boiling point: 235-237 ℃
-Density: 1.38g/cm³
-Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol and ether
Use:
2,4-dichloro-6-methylaniline is mainly used as an intermediate and reagent in organic synthesis, and is widely used in the fields of pesticide, dye and medicine. It has antifungal activity and can be used to control fungal diseases that harm crops. In addition, it can also be used in the production of dyes and pharmaceutical intermediates.
Method:
Generally, 2,4-dichloro-6-methylaniline is obtained by reacting 2-methylaniline with thionyl chloride, and then chlorinating. The specific steps are as follows:
1. Dissolve nitrosoaniline in dichloromethane.
2. Add about 50% sulfuric acid inhibition solution Dropwise into the reaction system.
3. Complete the reaction by adding sodium nitrite solution.
4. Use ammonia to adjust the pH value to neutral.
5. The reaction solution was added to saturated salt water, and the product was collected by centrifugation.
6. The above product is added dropwise to the prepared liquid thionyl chloride, and 2,4-dichloro-6-methylaniline is obtained by the reaction.
7. Distillation and crystallization purification product.
Safety Information:
2,4-dichloro-6-methylaniline is a toxic substance. Appropriate personal protective measures, such as wearing protective glasses, gloves and respiratory protection equipment, are required during operation. Avoid contact with skin, eyes and respiratory tract. If ingested or inhaled, should be timely medical treatment.
Nature:
-Appearance: Colorless or yellow crystal
-Melting point: 69-71 ℃
-Boiling point: 235-237 ℃
-Density: 1.38g/cm³
-Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol and ether
Use:
2,4-dichloro-6-methylaniline is mainly used as an intermediate and reagent in organic synthesis, and is widely used in the fields of pesticide, dye and medicine. It has antifungal activity and can be used to control fungal diseases that harm crops. In addition, it can also be used in the production of dyes and pharmaceutical intermediates.
Method:
Generally, 2,4-dichloro-6-methylaniline is obtained by reacting 2-methylaniline with thionyl chloride, and then chlorinating. The specific steps are as follows:
1. Dissolve nitrosoaniline in dichloromethane.
2. Add about 50% sulfuric acid inhibition solution Dropwise into the reaction system.
3. Complete the reaction by adding sodium nitrite solution.
4. Use ammonia to adjust the pH value to neutral.
5. The reaction solution was added to saturated salt water, and the product was collected by centrifugation.
6. The above product is added dropwise to the prepared liquid thionyl chloride, and 2,4-dichloro-6-methylaniline is obtained by the reaction.
7. Distillation and crystallization purification product.
Safety Information:
2,4-dichloro-6-methylaniline is a toxic substance. Appropriate personal protective measures, such as wearing protective glasses, gloves and respiratory protection equipment, are required during operation. Avoid contact with skin, eyes and respiratory tract. If ingested or inhaled, should be timely medical treatment.
Last Update：2024-04-09 20:52:54
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