2,4-Dichloropyridine-3-carboxaldehyde
2,4-Dichloropyridine-3-carboxaldehyde
CAS: 134031-24-6
Molecular Formula: C6H3Cl2NO
2,4-Dichloropyridine-3-carboxaldehyde - Names and Identifiers
| Name | 2,4-Dichloropyridine-3-carboxaldehyde |
| Synonyms | EOS-61543 2,4-dichloronicotinaldehyde 2,4-dichloronicotinaldehyde (en) 2,4-dichloropyridine-3-carbaldehyde 2,4-Dichloro-pyridin-3-carbaldehyde 2,4-Dichloropyridine-3-carboxaldehyde 3-Pyridinecarboxaldehyde,2,4-dichloro 2,4-DICHLOROPYRIDINE-3-CARBOXALDEHYDE 2,4-dichloro-3-pyridine Carboxaldehyde |
| CAS | 134031-24-6 |
| InChI | InChI=1/C6H3Cl2NO/c7-5-1-2-9-6(8)4(5)3-10/h1-3H |
| InChIKey | GWBHJHIZHNTJLA-UHFFFAOYSA-N |
2,4-Dichloropyridine-3-carboxaldehyde - Physico-chemical Properties
| Molecular Formula | C6H3Cl2NO |
| Molar Mass | 176 |
| Density | 1.488±0.06 g/cm3(Predicted) |
| Melting Point | 72-75℃ |
| Boling Point | 261.8±35.0 °C(Predicted) |
| Flash Point | 112.104°C |
| Vapor Presure | 0.011mmHg at 25°C |
| Appearance | White to yellow powder or crystal |
| Color | White to Orange to Green |
| pKa | -1.17±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Sensitive | Air Sensitive |
| Refractive Index | 1.608 |
| MDL | MFCD07437909 |
2,4-Dichloropyridine-3-carboxaldehyde - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
2,4-Dichloropyridine-3-carboxaldehyde - Reference Information
| Application | 2,4-dichlorotinic aldehyde is also called 2,4-dichlorotinic aldehyde, which can be used as a raw material from 2,4-dichloropyridine to first react with a strong base to obtain (2,4-dichloro-3-pyridyl) lithium, and then react with DMF to obtain 2,4-dichlorotinic aldehyde. |
| preparation | add 2 M LDA solution (8.11 mL,16.22 mmol) to the solution of 2, 4-dichloropyridine (2g,13.51 mmol) in tetrahydrofuran (20 mL) at -78 ℃ and stir the solution for 30 minutes. Add DMF(10.46 mL,135 mmol), stir the solution for 1 hour, then raise the temperature to room temperature. The reaction mixture was quenched with saturated NH4Cl solution and diluted with ethyl acetate (50 mL). The organic layer was washed with saturated NaHCO3(2 × 10 mL) and water (20 mL), dried by NaSO4 and concentrated under reduced pressure to obtain a yellow solid 2,4-dichloronicotinic aldehyde (2g,11.36 mmol,84% yield). |
Last Update：2024-04-09 02:00:06
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