2,4-dichloro-3-iodopy-ridine
2,4-dichloro-3-iodopy-ridine
CAS: 343781-36-2
Molecular Formula: C5H2Cl2IN
2,4-dichloro-3-iodopy-ridine - Names and Identifiers
| Name | 2,4-dichloro-3-iodopy-ridine |
| Synonyms | 2,4-Dichloro-3-iodopyridine 2,4-dichloro-3-iodopy-ridine Pyridine, 2,4-dichloro-3-iodo- |
| CAS | 343781-36-2 |
| InChI | InChI=1/C5H2Cl2IN/c6-3-1-2-9-5(7)4(3)8/h1-2H |
2,4-dichloro-3-iodopy-ridine - Physico-chemical Properties
| Molecular Formula | C5H2Cl2IN |
| Molar Mass | 273.89 |
| Density | 2.129±0.06 g/cm3(Predicted) |
| Melting Point | 90-94 °C |
| Boling Point | 290.3±35.0 °C(Predicted) |
| Flash Point | 129.395°C |
| Vapor Presure | 0.004mmHg at 25°C |
| pKa | -1.17±0.10(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Refractive Index | 1.652 |
| MDL | MFCD09033756 |
2,4-dichloro-3-iodopy-ridine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| UN IDs | UN 2811 |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
2,4-dichloro-3-iodopy-ridine - Reference Information
| Use | 2,4-dichloro-3-iodopyridine can be used as an intermediate in pharmaceutical synthesis, using 2,4-dichloropyridine as the reaction raw material, It is prepared by reacting with n-butyl lithium and iodine, and can be used to prepare another intermediate 2, 4-dichloro-3-trifluoromethylpyridine. It can also be obtained from 2, 4-dichloropyridine iodide or from 2, 4-dihydroxy-3-iodopyridine and phosphorus oxychloride. |
| preparation | in nitrogen atmosphere, n-butyl lithium (24.157ml,38.651mmol,1.6M in hexane) was added dropwise to a solution of 2, 4-dichloropyridine (5.2g,35.137mmol) and diisopropylamine (3.911g,38.651mmol) cooled at -78 ℃ in dry THF(40ml). The resulting reaction mixture was stirred at -78°C for 45 minutes, and then the solution of iodine (9.81g,38.651mmol) in dry THF (20ml) was dropwise added. The mixture was stirred at -78°C for 1 hour, allowed to be heated to room temperature, diluted with EtOAc and quenched with NH4Cl (aqueous saturated solution) and Na2S2O3 (aqueous saturated solution). The organic layers were separated, washed with NaHCO3 (aqueous saturated solution), dried (Na2SO4) and concentrated in vacuum. The crude product was purified by column chromatography (silica gel; heptane/DCM (up to 20%) as eluent). |
Last Update：2024-04-09 20:49:11
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