2,5-Dibromopyrazine
2,5-Dibromopyrazine
CAS: 23229-26-7
Molecular Formula: C4H2Br2N2
2,5-Dibromopyrazine - Names and Identifiers
| Name | 2,5-Dibromopyrazine |
| Synonyms | 5-Dibromopyrazine 2,5-DIBROMOPYRAZINE 2,5-Dibromopyrazine PYRAZINE,2,5-DIBROMO 2,5-bisbromopyrazine Pyrazine, 2,5-dibromo- 3,6-Dibromopyrazine, 2,5-Dibromo-1,4-diazine |
| CAS | 23229-26-7 |
| EINECS | 805-812-6 |
| InChI | InChI=1/C4H2Br2N2/c5-3-1-7-4(6)2-8-3/h1-2H |
| InChIKey | KIYKHEOWZLJZSB-UHFFFAOYSA-N |
2,5-Dibromopyrazine - Physico-chemical Properties
| Molecular Formula | C4H2Br2N2 |
| Molar Mass | 237.88 |
| Density | 2.197 |
| Melting Point | 45.0 to 49.0 °C |
| Boling Point | 234.0±35.0 °C(Predicted) |
| Flash Point | 95℃ |
| Vapor Presure | 0.082mmHg at 25°C |
| Appearance | Crystalline powder |
| Color | White to Orange to Green |
| pKa | -4.28±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.616 |
| MDL | MFCD08061601 |
2,5-Dibromopyrazine - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Hazard Class | IRRITANT |
2,5-Dibromopyrazine - Reference Information
| Application | 2,5-dibromopyrazine is a common organic synthon, which can be used as a molecular skeleton to participate in the synthesis of biologically active molecules. |
| Preparation | 5-bromo-2-pyrazinamine (D48, step 1)(317 mg, 1.82 mmol) was added to a solution of cooled (ice acetone bath) hydrobromic acid (48% aqueous solution)(2 ml). After stirring for 5 minutes, bromine (0.28 ml, 5.46 mmol) was added, and then an aqueous solution of sodium nitrite (314 mg, 4.55 mmol) was added dropwise within 15 minutes. The mixture is stirred for 30 minutes and heated to room temperature within 30 minutes. Add the solution of sodium hydroxide (2.6g) in water (7 ml) and stir the mixture for 1 hour. The mixture was extracted with dichloromethane. The dichloromethane layer is combined and evaporated in vacuum to obtain the target compound. |
Last Update：2024-04-09 15:16:49
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