2,5-Dichloronicotinaldehyde
2,5-dichloropyridine-3-carbaldehyde
CAS: 176433-49-1
Molecular Formula: C6H3Cl2NO
2,5-Dichloronicotinaldehyde - Names and Identifiers
2,5-Dichloronicotinaldehyde - Physico-chemical Properties
| Molecular Formula | C6H3Cl2NO |
| Molar Mass | 176 |
| Density | 1.488 |
| Melting Point | 89-92° |
| Boling Point | 256℃ |
| Flash Point | 109℃ |
| Vapor Presure | 0.016mmHg at 25°C |
| pKa | -3.75±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.608 |
| MDL | MFCD08056627 |
2,5-Dichloronicotinaldehyde - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R43 - May cause sensitization by skin contact |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
| Hazard Class | IRRITANT |
2,5-Dichloronicotinaldehyde - Reference Information
| overview | 2,5-dichlorotinic aldehyde can be used as an intermediate in pharmaceutical synthesis. If 2, 5-dichloronicotine is inhaled, please move the patient to fresh air. If the skin is in contact with the skin, remove the contaminated clothes, rinse the skin thoroughly with soapy water and clear water, and see a doctor if you feel uncomfortable. If the eyes are clear and in contact, the eyelids should be separated, rinsed with flowing water or normal saline, and seek medical treatment immediately. If you eat, rinse your mouth immediately, prohibit vomiting, and seek medical treatment immediately. |
| Preparation | 2,5-dichloronicotinaldehyde The preparation is as follows: 4-chloro-butyl-3-enonitrile (2.25g,22.3mmol) The dimethylformamide (8.6mL) solution is added with phosphoryl chloride (10.4mL,111mmol). The resulting reaction mixture was heated to 100°C overnight, cooled to 0°C and quenched with water. The product was extracted with dichloromethane, and the organic layer was dried with magnesium sulfate, filtered and concentrated in vacuum. Recrystallization from hexane gives 2, 5-dichlorotinic aldehyde. |
Last Update：2024-04-10 22:29:15
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CAS: 176433-49-1
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