2,6-DIFLUOROPYRIDINE
2,6-Difluoropyridine
CAS: 1513-65-1
Molecular Formula: C5H3F2N
2,6-DIFLUOROPYRIDINE - Names and Identifiers
| Name | 2,6-Difluoropyridine |
| Synonyms | 2,6-DifL CCRIS 1720 NSC 331814 2,6-difluoropyridi 2,6-Difluorpyridin 2,6-Difluoropyridine 2,6-DIFLUOROPYRIDINE Pyridine, 2,6-difluoro- 2, 6-2 fluoride pyridine 2,6- twofluorine pyridine 2-amino-6-(trifluoromethyl)pyrimidin-4-ol |
| CAS | 1513-65-1 |
| EINECS | 216-152-8 |
| InChI | InChI=1/C5H4F3N3O/c6-5(7,8)2-1-3(12)11-4(9)10-2/h1H,(H3,9,10,11,12) |
| InChIKey | MBTGBRYMJKYYOE-UHFFFAOYSA-N |
2,6-DIFLUOROPYRIDINE - Physico-chemical Properties
| Molecular Formula | C5H3F2N |
| Molar Mass | 115.08 |
| Density | 1.268 g/mL at 25 °C (lit.) |
| Boling Point | 124.5 °C/743 mmHg (lit.) |
| Flash Point | 93°F |
| Solubility | Not miscible or difficult to mix. |
| Vapor Presure | 0.643mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.268 |
| Color | Clear purple-red |
| BRN | 1422549 |
| pKa | -6.09±0.10(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Refractive Index | n20/D 1.437(lit.) |
2,6-DIFLUOROPYRIDINE - Risk and Safety
| Risk Codes | R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29333999 |
| Hazard Note | Toxic |
| Hazard Class | 3 |
| Packing Group | III |
2,6-DIFLUOROPYRIDINE - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| Application | 2, 6-difluoropyridine is widely used in the production of pharmaceuticals, pesticides, rubber and dyes; is an important intermediate of pesticide chemicals, used in the preparation of herbicides and insecticides, has important medicinal value and development prospects. |
| preparation | into a 500L enamel kettle, 252.2kg of sulfolane (1g/4ml) and 2, 6-dichloropyridine 50kg(1.0eq), then 43.2g of potassium fluoride (2.2eq) and 1.5kg of 18-crown -6(3%) were added in one time, stirred for 20min, then the temperature of the system is heated to 180~188 ℃, and the reaction is carried out at 180~188 ℃ for 6H. The product is transferred out of the reaction system by distillation in the reaction process, which drives the reaction to complete, the fractions were washed with water, separated, dried in organic phase, filtered, and the filtrate was Distilled. The fractions at 122~124 ℃ were collected, and the product was 30.4, yield 78.2%, GC purity: 99.5%. |
Last Update：2024-04-09 15:16:45
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