2,6-Dichloropyridine-4-boronicacid

2,6-Dichloropyridine-4-boronicacid - Names and Identifiers

Name	2,6-Dichloropyridin-4-ylboronic acid
Synonyms	2,6-Dichloropyridine-4-boronicacid 2,6-DICHLOROPYRIDIN-4-YLBORONIC ACID 2,6-Dichloropyridin-4-ylboronic acid (2,6-Dichloropyridin-4-yl)boronicaci 6-dichloropyridin-4-yl-4-boronic acid Boronic acid, B-(2,6-dichloro-4-pyridinyl)-
CAS	1072951-54-2

2,6-Dichloropyridine-4-boronicacid - Physico-chemical Properties

Molecular Formula	C5H4BCl2NO2
Molar Mass	191.81
Density	1.56±0.1 g/cm3(Predicted)
Boling Point	396.8±52.0 °C(Predicted)
pKa	5.57±0.11(Predicted)
Storage Condition	Inert atmosphere,Store in freezer, under -20°C

2,6-Dichloropyridine-4-boronicacid - Reference Information

Use

2, 6-dichloropyridine-4-boric acid can be used as an intermediate in pharmaceutical synthesis. It can be prepared by reaction under the action of n-butyl lithium. 2, 6-dichloropyridine-4-boronic acid can be used in the Suzuki reaction for the synthesis of pharmaceutical intermediates 2, 6-dichloro-4-[5-(trifluoromethyl) pyridine-2-yl] pyridine.

preparation method

under the protection of nitrogen, n-BuLi(3mL,2.5M hexane solution, 1.50 equivalent) is added dropwise to 2,6-dichloro -4-iodopyridine (1.40g,5.112mmol,1.00 equivalent) solution in tetrahydrofuran (20mL). The resulting solution was stirred at -78°C for 30min. Trimethyl borate (580mg,5.582mmol,1.10 equivalent) was added at -78 ℃, and the reactants were stirred at -78 ℃ for 1h. The obtained solution was stirred for another 12h at room temperature, and then quenched with 1.6g of pinacol and AcOH(0.6mL). The solids were filtered out and the liquid was concentrated under vacuum to give the title compound 2, 6-dichloropyridine-4-boric acid (1g, crude), a yellow solid.

Last Update：2024-04-09 01:59:58