2,6-dibromopyridin-3-ol

2,6-dibromopyridin-3-ol - Names and Identifiers

Name	2,6-dibromopyridin-3-ol
Synonyms	2,6-dibromopyridin-3-ol 3-Pyridinol, 2,6-dibromo- 2,6-DIBROMO-3-HYDROXYPYRIDINE 2,6-Dibromo-3-hydroxypyridine
CAS	6602-33-1
EINECS	229-548-0
InChI	InChI=1/C5H3Br2NO/c6-4-2-1-3(9)5(7)8-4/h1-2,9H

2,6-dibromopyridin-3-ol - Physico-chemical Properties

Molecular Formula	C5H3Br2NO
Molar Mass	252.89
Density	2.228±0.06 g/cm3(Predicted)
Melting Point	164.0 to 168.0 °C
Boling Point	369.3±37.0 °C(Predicted)
Flash Point	177.1°C
Solubility	soluble in Methanol
Vapor Presure	5.64E-06mmHg at 25°C
Appearance	powder to crystal
Color	White to Light yellow
pKa	3.86±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.654

2,6-dibromopyridin-3-ol - Introduction

2,6-dibromopyridin-3-ol is an organic compound with the chemical formula C5H3Br2NO. It is a white solid, soluble in organic solvents such as ethanol and methylene chloride. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: White solid
-melting point: about 120-125 ℃
-Boiling point: about 365 ℃
-Density: about 2.28g/cm³

Use:
2,6-dibromopyridin-3-ol is often used as a reagent in organic synthesis, especially in the preparation of benzopyrrole compounds. It can be used as a ligand and has certain applications in the field of coordination chemistry.

Preparation Method:
A commonly used preparation method is to introduce hydroxyl groups by reacting with NaOH starting from 2,6-dibromopyridine. Specific steps are as follows:
1. Dissolve 2,6-dibromopyridine in ethanol.
2. Add a small amount of sodium hydroxide (NaOH) to the solution.
3. The reaction is allowed to proceed for several hours under stirring.
4. 2,6-dibromopyridin-3-ol can be obtained by filtering, washing and drying the product.

Safety Information:
2,6-dibromopyridin-3-ol has certain toxicity, so pay attention to safety during operation. Avoid inhaling its dust or contact with skin, eyes or contaminated clothing. Wear appropriate protective gloves, goggles and protective clothing during use and operate in a well-ventilated area. In the case of accidental contact, rinse immediately with plenty of water and consult a professional.

Last Update：2024-04-10 22:29:15