2,6-dichlorobenzyloxime
2,6-Dichloro Benzyloxime
CAS: 25185-95-9
Molecular Formula: C7H5Cl2NO
2,6-dichlorobenzyloxime - Names and Identifiers
| Name | 2,6-Dichloro Benzyloxime |
| Synonyms | TIMTEC-BB SBB008012 2,6-DICHLOROBENZALDOXIM 2,6-DICHLOROBENZALOXIME 2,6-dichlorobenzyloxime 2,6-DICHLOROBENZALDOXIME 2,6-Dichloro Benzyloxime 2,6-Dichlorobenzaldoxime 2,6-Dichlorobenzyl oxime 2,6-dichloro-benzaldehydoxime 2,6-dichlorobenzaldehyde oxime Benzaldehyde, 2,6-dichloro-, oxime 1-(2,6-dichlorophenyl)-N-hydroxymethanimine (NE)-N-[(2,6-dichlorophenyl)methylidene]hydroxylamine |
| CAS | 25185-95-9 |
| EINECS | 246-720-0 |
| InChI | InChI=1/C7H5Cl2NO/c8-6-2-1-3-7(9)5(6)4-10-11/h1-4,11H/b10-4- |
| InChIKey | YBSXDWIAUZOFFV-ONNFQVAWSA-N |
2,6-dichlorobenzyloxime - Physico-chemical Properties
| Molecular Formula | C7H5Cl2NO |
| Molar Mass | 190.03 |
| Density | 1.38g/cm3 |
| Melting Point | 147 °C |
| Boling Point | 280.4°C at 760 mmHg |
| Flash Point | 123.4°C |
| Vapor Presure | 0.0018mmHg at 25°C |
| BRN | 2046662 |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.575 |
| MDL | MFCD00013938 |
| Physical and Chemical Properties | White crystals. |
| Use | Is a kind of pharmaceutical intermediates, mainly used in the manufacture of diclofenac benzylpenicillin sodium drug |
2,6-dichlorobenzyloxime - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| TSCA | Yes |
| Hazard Class | IRRITANT |
2,6-dichlorobenzyloxime - Nature
Open Data Verified Data
white crystals. The melting point was 149-150 °c.
Last Update：2024-01-02 23:10:35
2,6-dichlorobenzyloxime - Preparation Method
Open Data Verified Data
2,6-= chlorotoluene mixed with thionyl chloride, phosphorus trichloride as catalyst, under UV irradiation, heated to 200 ℃, chlorine gas was introduced for reaction, and liquid alkali was used to absorb tail gas, 2, 6-chlorobenzyl dichloride was obtained until the weight was increased to the theoretical weight, which was added to sulfuric acid and heated to 50-55 ℃ with stirring for 3H, then, hydroxylamine hydrochloride was added in portions, and the reaction product was slowly added to ice water after 3H of incubation, stirred, filtered, and washed with cold water.
Last Update：2022-01-01 10:50:40
2,6-dichlorobenzyloxime - Use
Open Data Verified Data
an intermediate in Medicine (diclofenac).
Last Update：2022-01-01 10:50:39
2,6-dichlorobenzyloxime - Safety
Open Data Verified Data
- This product is irritating to the skin. The workshop should be well ventilated, the equipment should be closed, the operator should wear masks and gloves.
- the use of lined plastic bags, woven bag jacket packaging. Store in a cool, dry, ventilated place, sunscreen, moisture. According to the general provisions of the storage and transportation of chemicals.
Last Update：2022-01-01 10:50:40
2,6-dichlorobenzyloxime - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Use | 2, 6-dichlorobenzaldehyde oxime is an important intermediate in the synthesis of benzoylurea insecticides. It is used to synthesize the next intermediate 2, 6-dichlorobenzonitrile, and finally obtain pesticide varieties such as fluoroburon, pyridorea, fluoridinamide, and lice-mite urea. In addition, 2, 6-dichlorobenzyl benzaldehyde oxime is also a kind of medicine Intermediate, for the production of diclofenazole penicillin sodium. As a pharmaceutical intermediate, used to make diclofenazole penicillin sodium. is a pharmaceutical intermediate, mainly used to make diclofenazole penicillin sodium drug |
| production method | 2, 6-dichlorotoluene is mixed with thionyl chloride, phosphorus trichloride is used as a catalyst, under ultraviolet light irradiation, heating to 200 ℃, passing chlorine gas for reaction, and absorbing the tail gas with liquid alkali until the weight is increased to the theoretical weight to obtain 2, 6-dichlorobenzyl dichloride, which is added to sulfuric acid, under stirring, heat to 50-55 ℃, react for 3 hours, then add hydroxylamine hydrochloride in times, keep the temperature for 3 hours, slowly add the reaction product into ice water, keep stirring, filter, and wash with cold water. The preparation method is to use 2, 6-dichlorobenzyl dichloride as raw material for oxime to obtain 2, 6-dichlorobenzaldehyde oxime. Add 2, 6-dichloro-dichlorobenzyl to sulfuric acid and heat slowly with stirring. React at 50~55 ℃ for 3h, then add hydroxylamine hydrochloride in several times, keep the temperature for 3h after adding, slowly add the reactants into ice water, stir continuously, filter after adding, rinse with a small amount of cold water to obtain 2, 6-dichlorobenzaldehyde oxime. |
Last Update：2024-04-10 22:29:15
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