2,8-BIS(TRIFLUOROMETHYL)QUINOLIN-4-OL
2,8-bis(trifluoromethyl)quinolin-4-ol
CAS: 35853-41-9
Molecular Formula: C11H5F6NO
2,8-BIS(TRIFLUOROMETHYL)QUINOLIN-4-OL - Names and Identifiers
2,8-BIS(TRIFLUOROMETHYL)QUINOLIN-4-OL - Physico-chemical Properties
| Molecular Formula | C11H5F6NO |
| Molar Mass | 281.15 |
| Density | 1.4837 (estimate) |
| Melting Point | 130-134°C(lit.) |
| Boling Point | 305.9±37.0 °C(Predicted) |
| Flash Point | 33.9°C |
| Vapor Presure | 10.9mmHg at 25°C |
| Appearance | Solid |
| Color | Clear colorless to slightly yellow |
| pKa | 5.84±0.40(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.384 |
| MDL | MFCD00075091 |
2,8-BIS(TRIFLUOROMETHYL)QUINOLIN-4-OL - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | 2811 |
| WGK Germany | 3 |
| HS Code | 29334900 |
| Hazard Class | IRRITANT |
2,8-BIS(TRIFLUOROMETHYL)QUINOLIN-4-OL - Introduction
2,8-bis(trifluoromethyl)quinolin-4-ol is an organic compound with the chemical formula C14H7F6NO. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 2,8-bis(trifluoromethyl)quinolin-4-ol is a yellow crystalline or powdery substance.
-Melting point: about 160-162°C.
-Solubility: It has good solubility in common organic solvents.
Use:
- 2,8-bis(trifluoromethyl)quinolin-4-ol can be used as a chemical reagent and can be used to synthesize other organic compounds in organic synthesis.
-It can also be applied to research in the field of medicine, as a raw material for drug intermediates or drug ligands.
Preparation Method:
-Generally, the preparation of 2,8-bis(trifluoromethyl)quinolin-4-ol can be completed by a fluorination synthesis reaction catalyzed by hydrofluoric acid. A specific process involves the trifluoromethylation reaction of hydroxyquinoline.
Safety Information: The toxicity and danger of
- 2,8-bis(trifluoromethyl)quinolin-4-ol has not been fully studied and evaluated. Therefore, use should follow laboratory safety procedures and take appropriate personal protective measures, such as wearing gloves, goggles and laboratory coats.
-The compound may be toxic to aquatic organisms and should be avoided from being discharged into water bodies.
-As with all chemicals, they should be stored in a cool, dry, well-ventilated place, away from ignition and flammable substances, and stored separately from oxidants and strong acids.
Nature:
-Appearance: 2,8-bis(trifluoromethyl)quinolin-4-ol is a yellow crystalline or powdery substance.
-Melting point: about 160-162°C.
-Solubility: It has good solubility in common organic solvents.
Use:
- 2,8-bis(trifluoromethyl)quinolin-4-ol can be used as a chemical reagent and can be used to synthesize other organic compounds in organic synthesis.
-It can also be applied to research in the field of medicine, as a raw material for drug intermediates or drug ligands.
Preparation Method:
-Generally, the preparation of 2,8-bis(trifluoromethyl)quinolin-4-ol can be completed by a fluorination synthesis reaction catalyzed by hydrofluoric acid. A specific process involves the trifluoromethylation reaction of hydroxyquinoline.
Safety Information: The toxicity and danger of
- 2,8-bis(trifluoromethyl)quinolin-4-ol has not been fully studied and evaluated. Therefore, use should follow laboratory safety procedures and take appropriate personal protective measures, such as wearing gloves, goggles and laboratory coats.
-The compound may be toxic to aquatic organisms and should be avoided from being discharged into water bodies.
-As with all chemicals, they should be stored in a cool, dry, well-ventilated place, away from ignition and flammable substances, and stored separately from oxidants and strong acids.
Last Update：2024-04-09 20:48:19
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