2-(4-CHLOROPHENYL)INDOLE
2-(4-chlorophenyl)-1H-indole
CAS: 1211-35-4
Molecular Formula: C14H10ClN
2-(4-CHLOROPHENYL)INDOLE - Names and Identifiers
| Name | 2-(4-chlorophenyl)-1H-indole |
| Synonyms | 2-P-CHLOROPHENYL INDOLE 2-(4-CHLOROPHENYL)INDOLE 2-(4-Chlorophenyl)indole 2-(4-CHLOROPHENYL)-1H-INDOLE 2-(4-chlorophenyl)-1H-indole 1H-Indole, 2-(4-chlorophenyl)- |
| CAS | 1211-35-4 |
| InChI | InChI=1/C14H10ClN/c15-12-7-5-10(6-8-12)14-9-11-3-1-2-4-13(11)16-14/h1-9,16H |
2-(4-CHLOROPHENYL)INDOLE - Physico-chemical Properties
| Molecular Formula | C14H10ClN |
| Molar Mass | 227.69 |
| Density | 1.271±0.06 g/cm3(Predicted) |
| Melting Point | 203 °C |
| Boling Point | 417.8±20.0 °C(Predicted) |
| Flash Point | 239°C |
| Vapor Presure | 8.36E-07mmHg at 25°C |
| pKa | 16.29±0.30(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.684 |
| MDL | MFCD00047159 |
2-(4-CHLOROPHENYL)INDOLE - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| HS Code | 29339900 |
2-(4-CHLOROPHENYL)INDOLE - Introduction
2-(4-Chlorophenyl) indole is an organic compound with the chemical formula C14H9ClN. It is a white to pale yellow crystalline solid. The following is a description of the properties, uses, preparation and safety information of 2-(4-chlorophenyl) indole:
Nature:
-Appearance: White to light yellow crystalline solid.
-Melting point: about 130-132 ℃.
-Solubility: Soluble in chloroform, ethanol, dichloromethane and other organic solvents, slightly soluble in water.
-Chemical reaction: 2-(4-chlorophenyl) indole can undergo a variety of organic reactions, such as substitution reactions and cyclization reactions.
Use:
-As an intermediate: 2-(4-chlorophenyl) indole can be used as an important intermediate in organic synthesis. It can participate in a variety of organic synthesis reactions, for the preparation of natural products containing indole structure, drugs and pesticides and other compounds.
-Drug research: Due to the special properties of its indole structure, 2-(4-chlorophenyl) indole has a wide range of applications in the field of drug research. It is used for the research and development and synthesis of anticancer drugs, antibacterial drugs, etc.
Preparation Method:
2-(4-chlorophenyl) indole preparation methods are mainly the following:
-Substitution reaction: 2-(4-chlorophenyl) indole is generated by reacting 2-indole base with 4-chlorophenyl bromide or chloride using sodium bicarbonate as an auxiliary base catalyst.
-Indole cyclization reaction: 2-(4-chlorophenyl) indole is generated by reaction of unsaturated compound with 4-chlorophenyl ketone and cyclization reaction.
Safety Information:
- 2-(4-chlorophenyl) indole has low toxicity, but it is still necessary to pay attention to safety precautions during use.
-Avoid contact with skin, eyes and respiratory tract, and maintain good ventilation during operation.
-Avoid contact with oxidants and acids during handling or storage.
-If you inhale or come into contact with the substance, wash the affected area immediately and seek medical help.
Nature:
-Appearance: White to light yellow crystalline solid.
-Melting point: about 130-132 ℃.
-Solubility: Soluble in chloroform, ethanol, dichloromethane and other organic solvents, slightly soluble in water.
-Chemical reaction: 2-(4-chlorophenyl) indole can undergo a variety of organic reactions, such as substitution reactions and cyclization reactions.
Use:
-As an intermediate: 2-(4-chlorophenyl) indole can be used as an important intermediate in organic synthesis. It can participate in a variety of organic synthesis reactions, for the preparation of natural products containing indole structure, drugs and pesticides and other compounds.
-Drug research: Due to the special properties of its indole structure, 2-(4-chlorophenyl) indole has a wide range of applications in the field of drug research. It is used for the research and development and synthesis of anticancer drugs, antibacterial drugs, etc.
Preparation Method:
2-(4-chlorophenyl) indole preparation methods are mainly the following:
-Substitution reaction: 2-(4-chlorophenyl) indole is generated by reacting 2-indole base with 4-chlorophenyl bromide or chloride using sodium bicarbonate as an auxiliary base catalyst.
-Indole cyclization reaction: 2-(4-chlorophenyl) indole is generated by reaction of unsaturated compound with 4-chlorophenyl ketone and cyclization reaction.
Safety Information:
- 2-(4-chlorophenyl) indole has low toxicity, but it is still necessary to pay attention to safety precautions during use.
-Avoid contact with skin, eyes and respiratory tract, and maintain good ventilation during operation.
-Avoid contact with oxidants and acids during handling or storage.
-If you inhale or come into contact with the substance, wash the affected area immediately and seek medical help.
Last Update：2024-04-09 15:17:51
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