2-氯-5-硝基-6-甲基吡啶
2-Chloro-6-methyl-5-nitropyridine
CAS: 22280-60-0
Molecular Formula: C6H5ClN2O2
2-氯-5-硝基-6-甲基吡啶 - Names and Identifiers
| Name | 2-Chloro-6-methyl-5-nitropyridine |
| Synonyms | TIMTEC-BB SBB003832 TIMTEC-BB SBB003830 2-CHLORO-5-NITRO-6-PICOLINE 6-CHLORO-3-NITRO-2-PICOLINE 2-CHLORO-5-NITRO-6-METHYLPYRIDINE 6-Chloro-2-methyl-3-nitropyridine 2-Chloro-6-methyl-5-nitropyridine 6-CHLORO-3-NITRO-2-METHYLPYRIDINE 2-CHLORO-6-METHYL-3-NITROPYRIDINE 2-CHLORO-6-METHYL-5-NITROPYRIDINE 6-Chloro-2-methyl-3-nitro-pyridine |
| CAS | 22280-60-0 |
| InChI | InChI=1/C6H5ClN2O2/c1-4-2-3-5(9(10)11)6(7)8-4/h2-3H,1H3 |
| InChIKey | GHSRMSJVYMITDX-UHFFFAOYSA-N |
2-氯-5-硝基-6-甲基吡啶 - Physico-chemical Properties
| Molecular Formula | C6H5ClN2O2 |
| Molar Mass | 172.57 |
| Density | 1.5610 (rough estimate) |
| Melting Point | 54-58 °C |
| Boling Point | 200°C (rough estimate) |
| Flash Point | 124.2°C |
| Vapor Presure | 0.00597mmHg at 25°C |
| Appearance | Powder |
| Color | Light beige to brown |
| pKa | -3.26±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.5500 (estimate) |
2-氯-5-硝基-6-甲基吡啶 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R22 - Harmful if swallowed |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| HS Code | 29333990 |
| Hazard Note | Harmful |
| Hazard Class | IRRITANT |
2-氯-5-硝基-6-甲基吡啶 - Reference Information
| introduction | 6-chloro-2-methyl-3-nitropyridine has a melting point of 54 to 58 degrees, a boiling point of 281.7±35.0 degrees (at one atmosphere), a density of 1.4, and a light beige to brown solid powder under normal temperature and pressure, which can be used as an organic synthesis intermediate. |
| Use | 6-chloro-2-methyl-3-nitropyridine can be used as an intermediate in pharmaceutical chemistry and organic synthesis, and the nitro group in its structure can be Under appropriate conditions, it is reduced to amino group (the reduction system is more iron powder plus acetic acid), because the reaction is carried out under acidic conditions, after the reaction is over, the pH of the reaction needs to be adjusted. In addition, because of the electron-deficient nature of the pyridine ring, the chlorine atoms on the pyridine ring can be attacked by nucleophiles under certain conditions to obtain dechlorinated functional products. |
| Synthesis method | For the synthesis of 6-chloro-2-methyl-3-nitropyridine, the conventional synthesis method is from its precursor 2-Hydroxy-6-methyl-5-nitropyridine starts and undergoes deoxychlorination reaction under the action of phosphorus oxychloride and phosphine pentachloride to obtain the target product. It is worth noting that the reaction needs to be carried out at a high temperature to better ensure the reaction efficiency and yield. |
Last Update：2024-04-09 21:11:58
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View History
2-氯-5-硝基-6-甲基吡啶
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BASIC ORANGE 15
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2-Propylzinc broMide, 0.5 M solution in THF, SpcSeal
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1,2-二氢-6-羟基-2-氧代-3-氰基吡啶