2-((1S,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropyl)-N-(5-fluoropyridin-2-yl)acetamide
Lemborexant
CAS: 1369764-02-2
Molecular Formula: C22H20F2N4O2
2-((1S,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropyl)-N-(5-fluoropyridin-2-yl)acetamide - Names and Identifiers
2-((1S,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropyl)-N-(5-fluoropyridin-2-yl)acetamide - Physico-chemical Properties
| Molecular Formula | C22H20F2N4O2 |
| Molar Mass | 410.4166 |
| Density | 1.347±0.06 g/cm3(Predicted) |
| Melting Point | 173 - 175°C |
| Boling Point | 596.1±50.0 °C(Predicted) |
| Solubility | DMSO: ≥ 30 mg/mL |
| Appearance | Form Solid, color White to Off-White |
| pKa | 12.30±0.40(Predicted) |
| Storage Condition | -20°C, Inert atmosphere |
| Use | The lemborexant of use is a dual inhibitor of OX1 and OX2 receptors, discovered and developed by Eisai. The compound inhibits orexin by competitively binding to 2 subtypes of orexin receptors (orexin receptor 1 and receptor 2). |
2-((1S,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropyl)-N-(5-fluoropyridin-2-yl)acetamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.437 ml | 12.183 ml | 24.365 ml |
| 5 mM | 0.487 ml | 2.437 ml | 4.873 ml |
| 10 mM | 0.244 ml | 1.218 ml | 2.437 ml |
| 5 mM | 0.049 ml | 0.244 ml | 0.487 ml |
Last Update：2024-01-02 23:10:35
2-((1S,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropyl)-N-(5-fluoropyridin-2-yl)acetamide - Nature
| solubility | DMSO (Slightly), Methanol (Slightly) |
Last Update：2024-04-10 22:29:15
2-((1S,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropyl)-N-(5-fluoropyridin-2-yl)acetamide - Application
lemborexant interfere with orexin neurotransmission and purposeful promotion of sleep initiation and maintenance. At present, Aisai is cooperating with Purdue to develop lemborexant for the treatment of various sleep disorders.
Last Update：2024-04-10 22:29:15
Supplier List
Spot supply
Product Name: Lemborexant Visit Supplier Webpage Request for quotationCAS: 1369764-02-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Lemborexant Visit Supplier Webpage Request for quotationCAS: 1369764-02-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History