2-((6,7-diMethoxyquinazolin-4-yl)thio)-5-Methyl-1,3,4-thiadiazole
SKLB1002
CAS: 1225451-84-2
Molecular Formula: C13H12N4O2S2
2-((6,7-diMethoxyquinazolin-4-yl)thio)-5-Methyl-1,3,4-thiadiazole - Names and Identifiers
2-((6,7-diMethoxyquinazolin-4-yl)thio)-5-Methyl-1,3,4-thiadiazole - Physico-chemical Properties
| Molecular Formula | C13H12N4O2S2 |
| Molar Mass | 320.39 |
| Density | 1.45±0.1 g/cm3(Predicted) |
| Melting Point | 193 °C |
| Boling Point | 522.4±60.0 °C(Predicted) |
| Appearance | powder to crystal |
| Color | White to Light yellow |
| pKa | -0.14±0.30(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| In vitro study | SKLB1002 exhibits significantly reduced cytotoxicity to normal human cell L-02. By inhibiting VEGF-induced phosphorylation of VEGFR2 kinase and downstream protein kinases, including ERK,FAK, and Src ,SKLB1002 significantly inhibits HUVEC proliferation, migration, invasion, and lumen formation. |
| In vivo study | In zebrafish embryos, SKLB1002 significantly blocked embryogenesis and tumor-induced angiogenesis with no or minimal effect on normal cell proliferation. In athymic mice xenografted with SW620 or HepG2, SKLB1002 (100 mg/kg/day, I. P.) caused significant tumor growth inhibition, inhibited tumor angiogenesis, and induced tumor cell apoptosis. In 4T1 and CT26 tumor models, SKLB1002 and local hyperthermia produce synergistic anti-tumor angiogenesis, anti-cancer, and apoptotic effects. |
2-((6,7-diMethoxyquinazolin-4-yl)thio)-5-Methyl-1,3,4-thiadiazole - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.121 ml | 15.606 ml | 31.212 ml |
| 5 mM | 0.624 ml | 3.121 ml | 6.242 ml |
| 10 mM | 0.312 ml | 1.561 ml | 3.121 ml |
| 5 mM | 0.062 ml | 0.312 ml | 0.624 ml |
Last Update：2024-01-02 23:10:35
2-((6,7-diMethoxyquinazolin-4-yl)thio)-5-Methyl-1,3,4-thiadiazole - Reference Information
| biological activity | SKLB1002 is a potent VEGFR2 inhibitor that competes with ATP with an IC50 of 32 nM. |
Last Update：2024-04-09 21:04:16
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Spot supply
Product Name: SKLB1002 Visit Supplier Webpage Request for quotationCAS: 1225451-84-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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