Molecular Formula | C18H21N5O3
|
Molar Mass | 355.39 |
Density | 1.33±0.1 g/cm3(Predicted) |
Melting Point | 221-223°C |
Solubility | DMSO: soluble10mg/mL, clear |
Appearance | White solid |
Color | white to beige |
pKa | 13.71±0.70(Predicted) |
Storage Condition | room temp |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
MDL | MFCD02007349 |
Use | HC-030031 |
In vitro study | HC-030031 rapidly and reversibly blocks the inward and outward currents induced by AITC or Formalin, and also inhibits the TRPA1 activation induced by N-methylmaleimide and electrophilic prostaglandins. HC-030031 did not inhibit TRPV1, TRPV3, TRPV4 hERG, or NaV1.2 channel-mediated currents. |
In vivo study | HC-030031 may be provided to the animal by oral administration, inhalation or injection. HC-030031 chronic inflammatory or neuropathic pain rat model was treated orally at a dose of 100 mg/kg, which significantly reversed the mechanical pain sensitivity, while the local injection (100 μg) into the inflamed mouse hind paw, attenuates toxic-mechanical hyperalgesia, but not thermal hyperalgesia. |