2-(1-(4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one
2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone
CAS: 571203-78-6
Molecular Formula: C30H31ClN4O4
2-(1-(4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one - Names and Identifiers
2-(1-(4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one - Physico-chemical Properties
| Molecular Formula | C30H31ClN4O4 |
| Molar Mass | 547.04 |
| Density | 1.28±0.1 g/cm3(Predicted) |
| Boling Point | 721.9±70.0 °C(Predicted) |
| Solubility | DMSO: soluble5mg/mL, clear (warmed) |
| Appearance | White solid |
| Color | white to beige |
| pKa | 5.54±0.10(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| MDL | MFCD09837984 |
| Physical and Chemical Properties | Bioactive Erastin is a ferroptosis activator that acts by acting on mitochondrial VDAC, selectively acting on tumor cells carrying the oncogene RAS. |
| Use | Erastin |
| Target | Target Value Ferroptosis |
| In vitro study | Erastin selectively kills the oncogenic Ras mutant cell line and triggers a unique fe-dependent, non-apoptotic cell death called ferroptosis. Erastin binds directly to VDAC2 and causes the production of ROS through an NADH-dependent manner leading to mitochondrial damage, inducing cell death through the RAS-RAF-MEK pathway in some tumor cells expressing activating mutations. In addition, erastin strongly enhances the effects of wild-type EGFR cells by inducing ROS-mediated CID (caspase-independent cell death). Erastin selectively kills oncogenic Ras mutant cell lines and triggers a unique fe-dependent, non-apoptotic cell death known as ferroptosis. Erastin binds directly to VDAC2 and causes the production of ROS through an NADH-dependent manner leading to mitochondrial damage, inducing cell death through the RAS-RAF-MEK pathway in some tumor cells expressing activating mutations. In addition, erastin strongly enhances the effects of wild-type EGFR cells by inducing ROS-mediated CID (caspase-independent cell death). |
| In vivo study | Intraperitoneal injection of erastin at well-tolerated doses dramatically inhibits HT-29 xenograft growth in severe combined immunodeficient mice. |
2-(1-(4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
2-(1-(4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one - Reference
| Reference Show more | 1. [IF=6.313] Yijia Yang et al."Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin."Antioxidants-Basel. 2022 Apr;11(4):710 |
2-(1-(4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.828 ml | 9.14 ml | 18.28 ml |
| 5 mM | 0.366 ml | 1.828 ml | 3.656 ml |
| 10 mM | 0.183 ml | 0.914 ml | 1.828 ml |
| 5 mM | 0.037 ml | 0.183 ml | 0.366 ml |
Last Update：2024-01-02 23:10:35
2-(1-(4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one - Introduction
2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone (compound A for short) it is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
Compound A is A solid crystal, and its chemical structure contains benzene ring and quinazoline ring. Its molecular formula is C27H29ClN2O4 and its molecular weight is 480.99g/mol.
Use:
Compound A has anti-inflammatory, antibacterial, antiviral and antitumor activities. Therefore, it is widely used in drug research and development in the field of medicine.
Preparation Method:
The method for preparing compound A is relatively complicated. Regular method includes the following steps:
1.4-chlorophenol was reacted with acetic anhydride under appropriate conditions to obtain 4-chlorophenylacetic acid;
2. Further converting 4-chlorophenylacetic acid into 4-chlorophenylacetic acid chloride;
3. Reaction of 4-chlorophenylacetic acid chloride with 1-piperazinoethanol to form 1-[4-[2-(4-chlorophenoxy) acetyl]-1-piperazinyl] ethanol;
4. Reaction of 1-[4-[2-(4-chlorophenoxy) acetyl]-1-piperazinyl] ethanol with 2-ethoxybenzaldehyde, the target product 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone was formed.
Safety Information:
The safety information for compound A is limited, and no extensive toxicological studies and safety evaluation data are currently available. When using or handling this compound, it is recommended to take appropriate laboratory safety operations, use protective equipment, and follow the relevant chemical safety procedures.
Nature:
Compound A is A solid crystal, and its chemical structure contains benzene ring and quinazoline ring. Its molecular formula is C27H29ClN2O4 and its molecular weight is 480.99g/mol.
Use:
Compound A has anti-inflammatory, antibacterial, antiviral and antitumor activities. Therefore, it is widely used in drug research and development in the field of medicine.
Preparation Method:
The method for preparing compound A is relatively complicated. Regular method includes the following steps:
1.4-chlorophenol was reacted with acetic anhydride under appropriate conditions to obtain 4-chlorophenylacetic acid;
2. Further converting 4-chlorophenylacetic acid into 4-chlorophenylacetic acid chloride;
3. Reaction of 4-chlorophenylacetic acid chloride with 1-piperazinoethanol to form 1-[4-[2-(4-chlorophenoxy) acetyl]-1-piperazinyl] ethanol;
4. Reaction of 1-[4-[2-(4-chlorophenoxy) acetyl]-1-piperazinyl] ethanol with 2-ethoxybenzaldehyde, the target product 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone was formed.
Safety Information:
The safety information for compound A is limited, and no extensive toxicological studies and safety evaluation data are currently available. When using or handling this compound, it is recommended to take appropriate laboratory safety operations, use protective equipment, and follow the relevant chemical safety procedures.
Last Update：2024-04-09 15:16:35
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Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Erastin Visit Supplier Webpage Request for quotationCAS: 571203-78-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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