2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethanol

2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethanol - Names and Identifiers

Name	1-AMINO-3,6,9-TRIOXAUNDECANYL-11-OL
Synonyms	t4egma NH2-PEG4 Amino-PEG4-alcohol 1-AMINO-3,6,9-TRIOXAUNDECANYL-11-OL 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)-ethano 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethanol 2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)ethylamine
CAS	86770-74-3

2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethanol - Physico-chemical Properties

Molecular Formula	C8H19NO4
Molar Mass	193.24
Density	1.068±0.06 g/cm3(Predicted)
Boling Point	301.6±27.0 °C(Predicted)
Solubility	Soluble in chloroform, dichloromethane, ethyl acetate and methanol
Appearance	solid or viscous liquid
Color	Colourless to Dark Brown
pKa	14.36±0.10(Predicted)
Storage Condition	-20°C
Sensitive	Easily absorbing moisture
Physical and Chemical Properties	Bioactive Amino-PEG4-alcohol is a PEG-based PROTAC linker that can be used to synthesize PROTAC. Amino-PEG4-alcohol is also a non-cleavable ADC linker for the synthesis of antibody-coupled drugs (ADC).
Use	Use 1-amino -3,6,9-trioxo -11-11 alcohol can be used to prepare a PROTAC compound targeting IDO1 degradation.

2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethanol - Upstream Downstream Industry

Raw Materials

3,6,9,12-Tetraoxatridecan-1-ol, 13,13,13-triphenyl-, 1-methanesulfonate
1H-Isoindole-1,3(2H)-dione, 2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]-
1-METHANESULFONYL-11-HYDROXY-3,6,9-TRIOXAUNDECANE
2,5,8,11-Tetraoxatridecan-13-ol, 1,1,1-triphenyl-
2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol
1-AZIDO-3,6,9-TRIOXAUNDECANE-11-OL
N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL
2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHANOL

2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethanol - Uses and synthesis methods

Introduction

1-amino -3,6, 9-triox-11-undiol is an alcohol derivative and can be used as a pharmaceutical intermediate.

Preparation

1-Amino -3,6, 9-Trioxo-11-11-11-11-alcohol can be prepared from triethylene glycol through a three-step reaction.

Target

PEGs

Non-cleavable

in vitro studies

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Last Update：2024-04-10 22:29:15